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6wt7

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Current revision (14:46, 6 March 2024) (edit) (undo)
 
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<StructureSection load='6wt7' size='340' side='right'caption='[[6wt7]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='6wt7' size='340' side='right'caption='[[6wt7]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6wt7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cragi Cragi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WT7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WT7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6wt7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Crassostrea_gigas Crassostrea gigas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WT7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WT7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1SY:CGAMP'>1SY</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">XP_011430837.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29159 CRAGI])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1SY:CGAMP'>1SY</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wt7 OCA], [http://pdbe.org/6wt7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wt7 RCSB], [http://www.ebi.ac.uk/pdbsum/6wt7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wt7 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wt7 OCA], [https://pdbe.org/6wt7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wt7 RCSB], [https://www.ebi.ac.uk/pdbsum/6wt7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wt7 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/STING_CRAGI STING_CRAGI]
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Stimulator of interferon genes (STING) is a receptor in human cells that senses foreign cyclic dinucleotides released during bacterial infection and endogenous cyclic GMP-AMP signalling during viral infection and antitumour immunity(1-5). STING shares no structural homology with other known signalling proteins(6-9), limiting functional analysis and preventing explanation of the origin of cyclic dinucleotide signalling in mammalian innate immunity. Here we discover functional STING homologues encoded within prokaryotic defence islands and reveal a conserved mechanism of signal activation. Crystal structures of bacterial STING define a minimal homodimeric scaffold that selectively responds to c-di-GMP synthesized by a neighbouring cGAS/DncV-like nucleotidyltransferase (CD-NTase) enzyme. Bacterial STING domains couple cyclic dinucleotide recognition with protein filament formation to drive TIR effector domain oligomerization and rapid NAD(+) cleavage. We reconstruct the evolutionary events following acquisition of STING into metazoan innate immunity and determine the structure of a full-length TIR-STING fusion from the Pacific oyster Crassostrea gigas. Comparative structural analysis demonstrates how metazoan-specific additions to the core STING scaffold enabled a switch from direct effector function to regulation of antiviral transcription. Together, our results explain the mechanism of STING-dependent signalling and reveal conservation of a functional cGAS-STING pathway in prokaryotic bacteriophage defence.
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STING cyclic dinucleotide sensing originated in bacteria.,Morehouse BR, Govande AA, Millman A, Keszei AFA, Lowey B, Ofir G, Shao S, Sorek R, Kranzusch PJ Nature. 2020 Sep 2. pii: 10.1038/s41586-020-2719-5. doi:, 10.1038/s41586-020-2719-5. PMID:32877915<ref>PMID:32877915</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6wt7" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cragi]]
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[[Category: Crassostrea gigas]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Govande, A A]]
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[[Category: Govande AA]]
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[[Category: Keszei, A F.A]]
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[[Category: Keszei AFA]]
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[[Category: Kranzusch, P J]]
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[[Category: Kranzusch PJ]]
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[[Category: Lowey, B]]
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[[Category: Lowey B]]
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[[Category: Millman, A]]
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[[Category: Millman A]]
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[[Category: Morehouse, B R]]
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[[Category: Morehouse BR]]
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[[Category: Ofir, G]]
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[[Category: Ofir G]]
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[[Category: Shao, S]]
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[[Category: Shao S]]
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[[Category: Sorek, R]]
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[[Category: Sorek R]]
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[[Category: Cyclic dinucleotide receptor]]
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[[Category: Immune effector]]
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[[Category: Immune system]]
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[[Category: Tir domain]]
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Current revision

Structure of a metazoan TIR-STING receptor from C. gigas in complex with 2',3'-cGAMP

PDB ID 6wt7

Drag the structure with the mouse to rotate

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OCA

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