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7ld0

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(New page: '''Unreleased structure''' The entry 7ld0 is ON HOLD Authors: Nanson, J.D., Gu, W., Luo, Z., Jia, X., Landsberg, M.J., Kobe, B., Ve, T. Description: Cryo-EM structure of ligand-free Hu...)
Current revision (14:59, 6 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 7ld0 is ON HOLD
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==Cryo-EM structure of ligand-free Human SARM1==
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<StructureSection load='7ld0' size='340' side='right'caption='[[7ld0]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7ld0]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LD0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LD0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ld0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ld0 OCA], [https://pdbe.org/7ld0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ld0 RCSB], [https://www.ebi.ac.uk/pdbsum/7ld0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ld0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SARM1_HUMAN SARM1_HUMAN] Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.<ref>PMID:15123841</ref> <ref>PMID:16964262</ref> <ref>PMID:16985498</ref> <ref>PMID:20306472</ref>
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Authors: Nanson, J.D., Gu, W., Luo, Z., Jia, X., Landsberg, M.J., Kobe, B., Ve, T.
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==See Also==
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*[[SARM1 3D structures|SARM1 3D structures]]
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Description: Cryo-EM structure of ligand-free Human SARM1
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Kobe, B]]
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__TOC__
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[[Category: Ve, T]]
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</StructureSection>
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[[Category: Jia, X]]
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[[Category: Homo sapiens]]
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[[Category: Luo, Z]]
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[[Category: Large Structures]]
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[[Category: Gu, W]]
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[[Category: Gu W]]
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[[Category: Nanson, J.D]]
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[[Category: Jia X]]
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[[Category: Landsberg, M.J]]
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[[Category: Kobe B]]
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[[Category: Landsberg MJ]]
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[[Category: Luo Z]]
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[[Category: Nanson JD]]
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[[Category: Ve T]]

Current revision

Cryo-EM structure of ligand-free Human SARM1

PDB ID 7ld0

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