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7lg1
From Proteopedia
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==Cryo-EM structure of human cGMP-bound CNGA1_E365Q channel in Na+/Ca2+== | ==Cryo-EM structure of human cGMP-bound CNGA1_E365Q channel in Na+/Ca2+== | ||
| - | <StructureSection load='7lg1' size='340' side='right'caption='[[7lg1]]' scene=''> | + | <StructureSection load='7lg1' size='340' side='right'caption='[[7lg1]], [[Resolution|resolution]] 2.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LG1 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7lg1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LG1 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lg1 OCA], [https://pdbe.org/7lg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lg1 RCSB], [https://www.ebi.ac.uk/pdbsum/7lg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lg1 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PCG:CYCLIC+GUANOSINE+MONOPHOSPHATE'>PCG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lg1 OCA], [https://pdbe.org/7lg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lg1 RCSB], [https://www.ebi.ac.uk/pdbsum/7lg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lg1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/CNGA1_HUMAN CNGA1_HUMAN] Retinitis pigmentosa. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CNGA1_HUMAN CNGA1_HUMAN] Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.[UniProtKB:Q00194] | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Ion channels 3D structures|Ion channels 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Han Y]] | [[Category: Han Y]] | ||
[[Category: Jiang Y]] | [[Category: Jiang Y]] | ||
[[Category: Xue J]] | [[Category: Xue J]] | ||
Current revision
Cryo-EM structure of human cGMP-bound CNGA1_E365Q channel in Na+/Ca2+
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Categories: Homo sapiens | Large Structures | Han Y | Jiang Y | Xue J
