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7ljl
From Proteopedia
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==Structure of the Enterobacter cloacae CD-NTase CdnD in complex with ATP== | ==Structure of the Enterobacter cloacae CD-NTase CdnD in complex with ATP== | ||
| - | <StructureSection load='7ljl' size='340' side='right'caption='[[7ljl]]' scene=''> | + | <StructureSection load='7ljl' size='340' side='right'caption='[[7ljl]], [[Resolution|resolution]] 1.45Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LJL FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7ljl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterobacter_cloacae Enterobacter cloacae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LJL FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ljl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ljl OCA], [https://pdbe.org/7ljl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ljl RCSB], [https://www.ebi.ac.uk/pdbsum/7ljl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ljl ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ljl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ljl OCA], [https://pdbe.org/7ljl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ljl RCSB], [https://www.ebi.ac.uk/pdbsum/7ljl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ljl ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CDND2_ENTCL CDND2_ENTCL] CBASS (cyclic oligonucleotide-based antiphage signaling system) provides immunity against bacteriophage. The CD-NTase protein synthesizes cyclic nucleotides in response to infection; these serve as specific second messenger signals. The signals activate a diverse range of effectors, leading to bacterial cell death and thus abortive phage infection. A type II-C(AAG) CBASS system (PubMed:32839535).<ref>PMID:32544385</ref> <ref>PMID:32839535</ref> Cyclic trinucleotide synthase that catalyzes the synthesis of 3',3',3'-cyclic AMP-AMP-GMP as the major product, a second messenger for cell signal transduction.<ref>PMID:30787435</ref> Protects E.coli against phage T2 infection. When the cdnD-cap2-cap3-cap4 operon is introduced in E.coli there is a more than 10(3) decrease in the efficiency of T2 plaque formation. The operon does not protect against phage T5 and only about 10-fold against T7.<ref>PMID:32544385</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Enterobacter cloacae]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Eaglesham JB]] | [[Category: Eaglesham JB]] | ||
Current revision
Structure of the Enterobacter cloacae CD-NTase CdnD in complex with ATP
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