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5suy
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5suy is ON HOLD Authors: Renko, M., Gammons, M.V., Bienz, M. Description: Domain-swapped dimer of human Dishevelled2 DEP domain: monoclinic crystal...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Domain-swapped dimer of human Dishevelled2 DEP domain: monoclinic crystal form crystallised from dimeric fraction== | |
| - | + | <StructureSection load='5suy' size='340' side='right'caption='[[5suy]], [[Resolution|resolution]] 1.88Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5suy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SUY FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | [[Category: Bienz | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5suy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5suy OCA], [https://pdbe.org/5suy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5suy RCSB], [https://www.ebi.ac.uk/pdbsum/5suy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5suy ProSAT]</span></td></tr> |
| - | [[Category: Gammons | + | </table> |
| - | [[Category: Renko | + | == Function == |
| + | [https://www.uniprot.org/uniprot/DVL2_HUMAN DVL2_HUMAN] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).<ref>PMID:19252499</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bienz M]] | ||
| + | [[Category: Gammons MV]] | ||
| + | [[Category: Renko M]] | ||
Current revision
Domain-swapped dimer of human Dishevelled2 DEP domain: monoclinic crystal form crystallised from dimeric fraction
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