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5t1d
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==Crystal structure of EBV gHgL/gp42/E1D1 complex== | ==Crystal structure of EBV gHgL/gp42/E1D1 complex== | ||
| - | <StructureSection load='5t1d' size='340' side='right' caption='[[5t1d]], [[Resolution|resolution]] 3.10Å' scene=''> | + | <StructureSection load='5t1d' size='340' side='right'caption='[[5t1d]], [[Resolution|resolution]] 3.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5t1d]] is a 5 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5t1d]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_4 Human gammaherpesvirus 4], [https://en.wikipedia.org/wiki/Human_herpesvirus_4_strain_B95-8 Human herpesvirus 4 strain B95-8] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T1D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T1D FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t1d OCA], [https://pdbe.org/5t1d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t1d RCSB], [https://www.ebi.ac.uk/pdbsum/5t1d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t1d ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/GH_EBVB9 GH_EBVB9] The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. Fusion of EBV with B-lymphocytes requires the additional receptor-binding protein gp42, which forms a complex with gH/gL. May also be required for virus attachment to epithelial cells.<ref>PMID:11021994</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human gammaherpesvirus 4]] | ||
| + | [[Category: Human herpesvirus 4 strain B95-8]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Jardetzky | + | [[Category: Jardetzky TS]] |
| - | [[Category: Sathiyamoorthy | + | [[Category: Sathiyamoorthy K]] |
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Current revision
Crystal structure of EBV gHgL/gp42/E1D1 complex
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