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5t4u
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the bromodomain of human BRPF1 in complex with a quinolinone ligand== | |
| + | <StructureSection load='5t4u' size='340' side='right'caption='[[5t4u]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5t4u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T4U FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=12Q:1-METHYLQUINOLIN-2(1H)-ONE'>12Q</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t4u OCA], [https://pdbe.org/5t4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t4u RCSB], [https://www.ebi.ac.uk/pdbsum/5t4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t4u ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Peregrin|Peregrin]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: | + | [[Category: Bayle ED]] |
| - | [[Category: | + | [[Category: Bountra C]] |
| - | [[Category: | + | [[Category: Brennan PE]] |
| - | [[Category: | + | [[Category: Edwards AM]] |
| - | [[Category: | + | [[Category: Fedorov O]] |
| - | [[Category: | + | [[Category: Fish P]] |
| - | [[Category: | + | [[Category: Igoe N]] |
| - | [[Category: | + | [[Category: Knapp S]] |
| - | [[Category: | + | [[Category: Mathea S]] |
| - | [[Category: | + | [[Category: Muller S]] |
| - | [[Category: Tallant | + | [[Category: Newman JA]] |
| - | [[Category: | + | [[Category: Nunez-Alonso G]] |
| + | [[Category: Savitsky P]] | ||
| + | [[Category: Tallant C]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Crystal structure of the bromodomain of human BRPF1 in complex with a quinolinone ligand
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bayle ED | Bountra C | Brennan PE | Edwards AM | Fedorov O | Fish P | Igoe N | Knapp S | Mathea S | Muller S | Newman JA | Nunez-Alonso G | Savitsky P | Tallant C | Von Delft F
