5t5f

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(New page: '''Unreleased structure''' The entry 5t5f is ON HOLD until Paper Publication Authors: Malito, E. Description: Neisseria meningitidis factor H binding protein in complex with monoclonal...)
Current revision (15:36, 6 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5t5f is ON HOLD until Paper Publication
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==Neisseria meningitidis factor H binding protein in complex with monoclonal antibody JAR5==
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<StructureSection load='5t5f' size='340' side='right'caption='[[5t5f]], [[Resolution|resolution]] 2.98&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5t5f]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T5F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.98&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t5f OCA], [https://pdbe.org/5t5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t5f RCSB], [https://www.ebi.ac.uk/pdbsum/5t5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t5f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FHBP_NEIMB FHBP_NEIMB] A bacterial surface lipoprotein that binds host (human) complement factor H (fH, gene CFH), binding contributes to the avoidance of complement-mediated lysis by N.meningitidis. Binding of fH to the bacteria surface is independent of bacterial sialic acid moieties (PubMed:16751403). fH binding affinity is high enough that it may sequester plasma fH, depleting its circulating levels and de-regulating complement in the host (Probable). This protein induces high levels of bactericidal antibodies in mice (PubMed:12642606, PubMed:15039331, PubMed:15664958, PubMed:21753121, PubMed:23133374).<ref>PMID:12642606</ref> <ref>PMID:15039331</ref> <ref>PMID:15664958</ref> <ref>PMID:16751403</ref> <ref>PMID:21753121</ref> <ref>PMID:23133374</ref> <ref>PMID:19225461</ref>
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Authors: Malito, E.
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==See Also==
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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Description: Neisseria meningitidis factor H binding protein in complex with monoclonal antibody JAR5
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Malito, E]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Neisseria meningitidis]]
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[[Category: Malito E]]

Current revision

Neisseria meningitidis factor H binding protein in complex with monoclonal antibody JAR5

PDB ID 5t5f

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