This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5t5f

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "5t5f" [edit=sysop:move=sysop])
Current revision (15:36, 6 March 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5t5f is ON HOLD until Paper Publication
+
==Neisseria meningitidis factor H binding protein in complex with monoclonal antibody JAR5==
 +
<StructureSection load='5t5f' size='340' side='right'caption='[[5t5f]], [[Resolution|resolution]] 2.98&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[5t5f]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T5F FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.98&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t5f OCA], [https://pdbe.org/5t5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t5f RCSB], [https://www.ebi.ac.uk/pdbsum/5t5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t5f ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/FHBP_NEIMB FHBP_NEIMB] A bacterial surface lipoprotein that binds host (human) complement factor H (fH, gene CFH), binding contributes to the avoidance of complement-mediated lysis by N.meningitidis. Binding of fH to the bacteria surface is independent of bacterial sialic acid moieties (PubMed:16751403). fH binding affinity is high enough that it may sequester plasma fH, depleting its circulating levels and de-regulating complement in the host (Probable). This protein induces high levels of bactericidal antibodies in mice (PubMed:12642606, PubMed:15039331, PubMed:15664958, PubMed:21753121, PubMed:23133374).<ref>PMID:12642606</ref> <ref>PMID:15039331</ref> <ref>PMID:15664958</ref> <ref>PMID:16751403</ref> <ref>PMID:21753121</ref> <ref>PMID:23133374</ref> <ref>PMID:19225461</ref>
-
Authors: Malito, E.
+
==See Also==
-
 
+
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
-
Description: Neisseria meningitidis factor H binding protein in complex with monoclonal antibody JAR5
+
== References ==
-
[[Category: Unreleased Structures]]
+
<references/>
-
[[Category: Malito, E]]
+
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Mus musculus]]
 +
[[Category: Neisseria meningitidis]]
 +
[[Category: Malito E]]

Current revision

Neisseria meningitidis factor H binding protein in complex with monoclonal antibody JAR5

PDB ID 5t5f

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5t5f"
Personal tools