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5tre

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'''Unreleased structure'''
 
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The entry 5tre is ON HOLD until Oct 26 2018
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==Zinc and the Iron Donor Frataxin Regulate Oligomerization of the Scaffold Protein to Form New Fe-S Cluster Assembly Centers==
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<SX load='5tre' size='340' side='right' viewer='molstar' caption='[[5tre]], [[Resolution|resolution]] 15.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5tre]] is a 48 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TRE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 15.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tre OCA], [https://pdbe.org/5tre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tre RCSB], [https://www.ebi.ac.uk/pdbsum/5tre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tre ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ISU1_YEAST ISU1_YEAST] Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold proteins ISU1 and ISU2. In a second step, the cluster is released from ISU1/ISU2, transferred to glutaredoxin GRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISU1/ISU2 depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin (YFH1) as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase ARH1 and ferredoxin YAH1, which receive their electrons from NADH. Fe-S cluster release from ISU1/ISU2 is achieved by interaction with the Hsp70 chaperone SSQ1, assisted by the DnaJ-like co-chaperone JAC1 and the nucleotide exchange factor MGE1. ISU1 is the major isoform in yeast, while ISU2 is not detectable in cells grown to stationary phase (PubMed:10588895, PubMed:12970193, PubMed:14741370, PubMed:15123690, PubMed:16341089, PubMed:16431909, PubMed:23615440, PubMed:25358379).<ref>PMID:10588895</ref> <ref>PMID:12970193</ref> <ref>PMID:14741370</ref> <ref>PMID:15123690</ref> <ref>PMID:16341089</ref> <ref>PMID:16431909</ref> <ref>PMID:23615440</ref> <ref>PMID:25358379</ref>
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Authors: Ranatunga, W., Gakh, O., Galeano, B.K., Smith IV, D.Y., Thompson, J.R., Isaya, G.
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==See Also==
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*[[Frataxin 3D Structures|Frataxin 3D Structures]]
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Description: Zinc and the Iron Donor Frataxin Regulate Oligomerization of the Scaffold Protein to Form New Fe-S Cluster Assembly Centers
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Isaya, G]]
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__TOC__
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[[Category: Thompson, J.R]]
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</SX>
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[[Category: Gakh, O]]
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[[Category: Large Structures]]
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[[Category: Smith Iv, D.Y]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Galeano, B.K]]
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[[Category: Gakh O]]
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[[Category: Ranatunga, W]]
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[[Category: Galeano BK]]
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[[Category: Isaya G]]
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[[Category: Ranatunga W]]
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[[Category: Smith IV DY]]
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[[Category: Thompson JR]]

Current revision

Zinc and the Iron Donor Frataxin Regulate Oligomerization of the Scaffold Protein to Form New Fe-S Cluster Assembly Centers

5tre, resolution 15.60Å

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