This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5tus
From Proteopedia
(Difference between revisions)
m (Protected "5tus" [edit=sysop:move=sysop]) |
|||
| (6 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Potent competitive inhibition of human ribonucleotide reductase by a novel non-nucleoside small molecule== | |
| + | <StructureSection load='5tus' size='340' side='right'caption='[[5tus]], [[Resolution|resolution]] 2.66Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5tus]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TUS FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.66Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7LL:2-hydroxy-N-[(Z)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide'>7LL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tus OCA], [https://pdbe.org/5tus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tus RCSB], [https://www.ebi.ac.uk/pdbsum/5tus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tus ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RIR1_HUMAN RIR1_HUMAN] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | ||
| - | + | ==See Also== | |
| - | + | *[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Alam | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Alam I]] |
| + | [[Category: Dealwis CG]] | ||
| + | [[Category: Mohammed FA]] | ||
Current revision
Potent competitive inhibition of human ribonucleotide reductase by a novel non-nucleoside small molecule
| |||||||||||
