Structural Biology
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| - | + | [[Image:373px-X ray diffraction.png|250px|right|thumb| The Steps toward [[Empirical models|Elucidating the Structures]] of Biological Macromolecules by [[X-ray crystallography]].]] | |
| + | [[Structural Biology]] is a branch of molecular biology & biochemistry concerned with the the molecular structure of biological macromolecules like proteins and [[Nucleic Acids|nucleic acids]]. It focuses on determining the structure of macromolecules to better understand their function and how to manipulate these macromolecules to develop therapeutics and broaden our understanding of biological phenomena. | ||
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| + | Articles in Proteopedia concerning [[Structural Biology]] include: | ||
| + | {{#tree:id=SBTopic|openlevels=0| | ||
| + | * [[About Macromolecular Structure]] - An Index to pages that explain structural biology terms and concepts. | ||
* Methods of Structure Determination | * Methods of Structure Determination | ||
| + | ** [[Empirical models]]: the 3 major methods for determining macromolecular structures. | ||
| + | ** NMR | ||
| + | *** [[NMR Ensembles of Models]] | ||
| + | *** [[Quality assessment for molecular models]] | ||
** X-Ray Crystallography | ** X-Ray Crystallography | ||
| - | *** [[ | + | *** [[Anisotropic refinement]] |
*** [[Asymmetric Unit]] | *** [[Asymmetric Unit]] | ||
*** [[Biological Unit]] | *** [[Biological Unit]] | ||
*** [[Electron density maps]] | *** [[Electron density maps]] | ||
| - | ** | + | *** [[Free R]] |
| - | *** [[ | + | *** [[Quality assessment for molecular models]] |
| - | + | *** [[R value]] | |
| + | *** [[Resolution]] | ||
| + | *** [[Temperature value]] | ||
| + | *** [[X-ray crystallography]] | ||
* Methods of Structure & Sequence Analysis | * Methods of Structure & Sequence Analysis | ||
** Structural Analysis & Visualization | ** Structural Analysis & Visualization | ||
| - | *** [[ | + | *** [[Atomic coordinate file]] |
*** [[Chime]] | *** [[Chime]] | ||
| - | + | *** [[CPK]] - Corey-Pauling-Koltun spacefilling molecular models and color scheme for elements | |
| - | + | *** [[DRuMS]] - set of standard color schemes for macromolecular visualization | |
| - | + | ||
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*** [[User:Wayne Decatur/Generate Unfolded Structures|Generate Unfolded Structures]] | *** [[User:Wayne Decatur/Generate Unfolded Structures|Generate Unfolded Structures]] | ||
| + | *** [[Improving published models]] | ||
| + | *** [[Molecular modeling and visualization software]] | ||
| + | *** [[Morphs]] | ||
| + | *** [[PDB identification code]] | ||
| + | *** [[Protein Data Bank]] | ||
| + | *** [[Ramachandran Plots]] | ||
| + | *** [[Structural alignment tools]] | ||
| + | *** [[User:Wayne Decatur/Teaching Proteopedia|Teaching Proteopedia]] | ||
*** Homology Model | *** Homology Model | ||
**** [[User:Wayne Decatur/Homology Modeling|Homology Modeling]] | **** [[User:Wayne Decatur/Homology Modeling|Homology Modeling]] | ||
**** [[User:Emi Nakayama/TRIM5a Homology Models|TRIM5a Homology Models]] - Differences in models as a function of their templates | **** [[User:Emi Nakayama/TRIM5a Homology Models|TRIM5a Homology Models]] - Differences in models as a function of their templates | ||
| - | *** [[ | + | *** Jmol |
| + | **** [[FirstGlance in Jmol]] | ||
| + | **** [[S347/Visualising protein structure|Visualising Protein Structure]] - Introduction to Jmol | ||
** Sequence Analysis | ** Sequence Analysis | ||
*** [[User:Wayne Decatur/Sequence analysis tools|Sequence Analysis Tools]] | *** [[User:Wayne Decatur/Sequence analysis tools|Sequence Analysis Tools]] | ||
}} | }} | ||
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| + | To view automatically seeded indices concerning [[Structural Biology]] See: | ||
| + | *[[: Category:Macromolecule|Macromolecule]] | ||
| + | *[[: Category:Nmr|NMR]] | ||
| + | *[[:Category:Structure|Structure]] | ||
| + | *[[: Category:X-ray|X-Ray]] | ||
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| + | <br /> | ||
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| + | ==See Also== | ||
| + | *[[About Macromolecular Structure]], an index to pages explaining terms and concepts. | ||
| + | *[[Index pages]] | ||
Current revision
Structural Biology is a branch of molecular biology & biochemistry concerned with the the molecular structure of biological macromolecules like proteins and nucleic acids. It focuses on determining the structure of macromolecules to better understand their function and how to manipulate these macromolecules to develop therapeutics and broaden our understanding of biological phenomena.
Articles in Proteopedia concerning Structural Biology include:
To view automatically seeded indices concerning Structural Biology See:
See Also
- About Macromolecular Structure, an index to pages explaining terms and concepts.
- Index pages
