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8rkf
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the ZP-N1 and ZP-N2 domains of human ZP2 (hZP2-N1N2)== | |
| - | + | <StructureSection load='8rkf' size='340' side='right'caption='[[8rkf]], [[Resolution|resolution]] 3.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8rkf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RKF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rkf OCA], [https://pdbe.org/8rkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rkf RCSB], [https://www.ebi.ac.uk/pdbsum/8rkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rkf ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/ZP2_HUMAN ZP2_HUMAN] Female infertility due to zona pellucida defect. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ZP2_HUMAN ZP2_HUMAN] Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy (PubMed:29895852). The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor (PubMed:29895852).<ref>PMID:29895852</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Dioguardi E]] | ||
| + | [[Category: Jovine L]] | ||
| + | [[Category: Stsiapanava A]] | ||
| + | [[Category: De Sanctis D]] | ||
Current revision
Crystal structure of the ZP-N1 and ZP-N2 domains of human ZP2 (hZP2-N1N2)
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