1hqw

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(New page: 200px<br /><applet load="1hqw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hqw, resolution 2.40&Aring;" /> '''CRYSTAL STRUCTURE OF...)
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[[Image:1hqw.gif|left|200px]]<br /><applet load="1hqw" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1hqw, resolution 2.40&Aring;" />
 
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'''CRYSTAL STRUCTURE OF THE COMPLEX OF CONCANAVALIN A WITH A TRIPEPTIDE YPY'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF THE COMPLEX OF CONCANAVALIN A WITH A TRIPEPTIDE YPY==
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The X-ray structure analysis of a cross-linked crystal of concanavalin A, soaked with the tripeptide molecule as the probe molecule showed electron, density corresponding to full occupation in the binding pocket. The site, lies on the surface of concanavalin A and is surrounded by three, symmetry-related molecules. The crystal structure of the tripeptide, complex was refined at 2.4-A resolution to an R-factor of 17.5%, (Rfree, factor of 23.7%), with an RMS deviation in bond distances of 0.01 A. The, model includes all 237 residue of concanavalin A, 1 manganese ion, 1, calcium ion, 161 water molecules, 1 glutaraldehyde molecule, and 1, tripeptide molecule. This X-ray structure analysis also provides an, approach to mapping the binding surface of crystalline protein with a, probe molecule that is dissolved in a mixture of organic solvent with, water or in neat organic solvent but is hardly dissolved in aqueous, solution.
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<StructureSection load='1hqw' size='340' side='right'caption='[[1hqw]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1hqw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HQW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PTD:PENTANEDIAL'>PTD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hqw OCA], [https://pdbe.org/1hqw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hqw RCSB], [https://www.ebi.ac.uk/pdbsum/1hqw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hqw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CONA_CANEN CONA_CANEN] D-mannose specific lectin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hq/1hqw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hqw ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1HQW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis] with MN, CA and PTD as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HQW OCA].
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*[[Concanavalin 3D structures|Concanavalin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of the complex of concanavalin A and tripeptide., Zhang Z, Qian M, Huang Q, Jia Y, Tang Y, Wang K, Cui D, Li M, J Protein Chem. 2001 Jan;20(1):59-65. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11330349 11330349]
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[[Category: Canavalia ensiformis]]
[[Category: Canavalia ensiformis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Cui, D.]]
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[[Category: Cui D]]
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[[Category: Huang, Q.]]
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[[Category: Huang Q]]
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[[Category: Jia, Y.]]
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[[Category: Jia Y]]
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[[Category: Li, M.]]
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[[Category: Li M]]
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[[Category: Qian, M.]]
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[[Category: Qian M]]
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[[Category: Tang, Y.]]
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[[Category: Tang Y]]
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[[Category: Wang, K.]]
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[[Category: Wang K]]
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[[Category: Zhang, Z.]]
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[[Category: Zhang Z]]
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[[Category: CA]]
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[[Category: MN]]
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[[Category: PTD]]
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[[Category: beta sheets]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 16:45:45 2007''
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Current revision

CRYSTAL STRUCTURE OF THE COMPLEX OF CONCANAVALIN A WITH A TRIPEPTIDE YPY

PDB ID 1hqw

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