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1jg5
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==CRYSTAL STRUCTURE OF RAT GTP CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN, GFRP== | ==CRYSTAL STRUCTURE OF RAT GTP CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN, GFRP== | ||
| - | <StructureSection load='1jg5' size='340' side='right' caption='[[1jg5]], [[Resolution|resolution]] 2.60Å' scene=''> | + | <StructureSection load='1jg5' size='340' side='right'caption='[[1jg5]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1jg5]] is a 5 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1jg5]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JG5 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jg5 OCA], [https://pdbe.org/1jg5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jg5 RCSB], [https://www.ebi.ac.uk/pdbsum/1jg5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jg5 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/GFRP_RAT GFRP_RAT] Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jg5 ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jg5 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis in mammals through feedback inhibition of GTP cyclohydrolase I. This mechanism is mediated by a regulatory subunit called GTP cyclohydrolase I feedback regulatory protein (GFRP). The 2.6 A resolution crystal structure of rat GFRP shows that the protein forms a pentamer. This indicates a model for the interaction of mammalian GTP cyclohydrolase I with its regulator, GFRP. Kinetic investigations of human GTP cyclohydrolase I in complex with rat and human GFRP showed similar regulatory effects of both GFRP proteins. | ||
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| - | Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP.,Bader G, Schiffmann S, Herrmann A, Fischer M, Gutlich M, Auerbach G, Ploom T, Bacher A, Huber R, Lemm T J Mol Biol. 2001 Oct 5;312(5):1051-7. PMID:11580249<ref>PMID:11580249</ref> | ||
| - | |||
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 1jg5" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Auerbach | + | [[Category: Rattus norvegicus]] |
| - | [[Category: Bacher | + | [[Category: Auerbach G]] |
| - | [[Category: Bader | + | [[Category: Bacher A]] |
| - | [[Category: Fischer | + | [[Category: Bader G]] |
| - | [[Category: Gutlich | + | [[Category: Fischer M]] |
| - | [[Category: Herrmann | + | [[Category: Gutlich M]] |
| - | [[Category: Huber | + | [[Category: Herrmann A]] |
| - | [[Category: Lemm | + | [[Category: Huber R]] |
| - | [[Category: Ploom | + | [[Category: Lemm T]] |
| - | [[Category: Schiffmann | + | [[Category: Ploom T]] |
| - | + | [[Category: Schiffmann S]] | |
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Current revision
CRYSTAL STRUCTURE OF RAT GTP CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN, GFRP
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Categories: Large Structures | Rattus norvegicus | Auerbach G | Bacher A | Bader G | Fischer M | Gutlich M | Herrmann A | Huber R | Lemm T | Ploom T | Schiffmann S
