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1jj9

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[[Image:1jj9.png|left|200px]]
 
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{{STRUCTURE_1jj9| PDB=1jj9 | SCENE= }}
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==Crystal Structure of MMP8-Barbiturate Complex Reveals Mechanism for Collagen Substrate Recognition==
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<StructureSection load='1jj9' size='340' side='right'caption='[[1jj9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Crystal Structure of MMP8-Barbiturate Complex Reveals Mechanism for Collagen Substrate Recognition===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1jj9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JJ9 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11278347}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BBT:2-HYDROXY-5-[4-(2-HYDROXY-ETHYL)-PIPERIDIN-1-YL]-5-PHENYL-1H-PYRIMIDINE-4,6-DIONE'>BBT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jj9 OCA], [https://pdbe.org/1jj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jj9 RCSB], [https://www.ebi.ac.uk/pdbsum/1jj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jj9 ProSAT]</span></td></tr>
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[[1jj9]] is a 1 chain structure of [[Matrix metalloproteinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JJ9 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MMP8_HUMAN MMP8_HUMAN] Can degrade fibrillar type I, II, and III collagens.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/1jj9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jj9 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Matrix metalloproteinase|Matrix metalloproteinase]]
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:011278347</ref><ref group="xtra">PMID:015616985</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Neutrophil collagenase]]
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[[Category: Large Structures]]
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[[Category: Bode, W.]]
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[[Category: Bode W]]
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[[Category: Brandstetter, H.]]
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[[Category: Brandstetter H]]
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[[Category: Engh, R A.]]
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[[Category: Engh RA]]
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[[Category: Glitz, D.]]
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[[Category: Glitz D]]
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[[Category: Grams, F.]]
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[[Category: Grams F]]
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[[Category: Huber, R.]]
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[[Category: Huber R]]
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[[Category: Krell, H W.]]
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[[Category: Krell H-W]]
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[[Category: Lang, A.]]
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[[Category: Lang A]]
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[[Category: Cis-peptide bond]]
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[[Category: Conformational transition]]
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[[Category: Hydrolase]]
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[[Category: Mmp-8]]
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[[Category: Substrate recognition]]
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Current revision

Crystal Structure of MMP8-Barbiturate Complex Reveals Mechanism for Collagen Substrate Recognition

PDB ID 1jj9

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