1jsz

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[[Image:1jsz.png|left|200px]]
 
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{{STRUCTURE_1jsz| PDB=1jsz | SCENE= }}
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==Crystal Structure Analysis of N7,9-dimethylguanine-VP39 complex==
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<StructureSection load='1jsz' size='340' side='right'caption='[[1jsz]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
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===Crystal Structure Analysis of N7,9-dimethylguanine-VP39 complex===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1jsz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JSZ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12056899}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDM:7,9-DIMETHYLGUANINE'>NDM</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jsz OCA], [https://pdbe.org/1jsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jsz RCSB], [https://www.ebi.ac.uk/pdbsum/1jsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jsz ProSAT]</span></td></tr>
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[[1jsz]] is a 1 chain structure of [[Poly(A) Polymerase]] with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSZ OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MCE_VACCW MCE_VACCW] Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. At the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap. At the 3' end, functions as a processivity factor which stimulates the activity of the viral poly(A) polymerase VP55 that creates mRNA's poly(A) tail. In the presence of VP39, VP55 does not dissociate from the RNA allowing tail elongation to around 250 adenylates.<ref>PMID:1313572</ref> <ref>PMID:1670500</ref> <ref>PMID:12359447</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/1jsz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jsz ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Poly(A) Polymerase|Poly(A) Polymerase]]
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*[[Poly(A) polymerase 3D structures|Poly(A) polymerase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012056899</ref><references group="xtra"/>
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__TOC__
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[[Category: Polynucleotide adenylyltransferase]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Vaccinia virus]]
[[Category: Vaccinia virus]]
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[[Category: Gershon, P D.]]
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[[Category: Gershon PD]]
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[[Category: Hu, G.]]
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[[Category: Hu G]]
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[[Category: Oguro, A.]]
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[[Category: Oguro A]]
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[[Category: Quiocho, F A.]]
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[[Category: Quiocho FA]]
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[[Category: Methyltransferase]]
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[[Category: Mrna cap-binding protein]]
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[[Category: Transferase]]
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[[Category: Vp39]]
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Current revision

Crystal Structure Analysis of N7,9-dimethylguanine-VP39 complex

PDB ID 1jsz

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