1q1c

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[[Image:1q1c.png|left|200px]]
 
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{{STRUCTURE_1q1c| PDB=1q1c | SCENE= }}
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==Crystal structure of N(1-260) of human FKBP52==
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<StructureSection load='1q1c' size='340' side='right'caption='[[1q1c]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===Crystal structure of N(1-260) of human FKBP52===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1q1c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q1C FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15159550}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1c OCA], [https://pdbe.org/1q1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q1c RCSB], [https://www.ebi.ac.uk/pdbsum/1q1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q1c ProSAT]</span></td></tr>
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[[1q1c]] is a 1 chain structure of [[FK506 binding protein]] and [[Human FKBP52]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1C OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FKBP4_HUMAN FKBP4_HUMAN] Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.<ref>PMID:1279700</ref> <ref>PMID:1376003</ref> <ref>PMID:2378870</ref> <ref>PMID:19945390</ref> <ref>PMID:21730050</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q1/1q1c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q1c ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[FK506 binding protein|FK506 binding protein]]
*[[FK506 binding protein|FK506 binding protein]]
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*[[FKBP 3D structures|FKBP 3D structures]]
*[[Human FKBP52|Human FKBP52]]
*[[Human FKBP52|Human FKBP52]]
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*[[Wheat FKBP73|Wheat FKBP73]]
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:015159550</ref><ref group="xtra">PMID:010731432</ref><ref group="xtra">PMID:015937899</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Large Structures]]
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[[Category: Ding, Y.]]
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[[Category: Ding Y]]
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[[Category: Li, P.]]
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[[Category: Li P]]
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[[Category: Lou, Z.]]
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[[Category: Lou Z]]
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[[Category: Rao, Z.]]
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[[Category: Rao Z]]
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[[Category: Shen, B.]]
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[[Category: Shen B]]
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[[Category: Shu, C.]]
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[[Category: Shu C]]
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[[Category: Wu, B.]]
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[[Category: Wu B]]
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[[Category: Isomerase]]
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[[Category: Nuclear protein]]
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[[Category: Phosphorylation]]
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[[Category: Rotamase]]
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[[Category: Tpr repeat]]
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Current revision

Crystal structure of N(1-260) of human FKBP52

PDB ID 1q1c

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