1qz2

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{{Seed}}
 
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[[Image:1qz2.png|left|200px]]
 
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==Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90==
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The line below this paragraph, containing "STRUCTURE_1qz2", creates the "Structure Box" on the page.
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<StructureSection load='1qz2' size='340' side='right'caption='[[1qz2]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qz2]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QZ2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qz2 OCA], [https://pdbe.org/1qz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qz2 RCSB], [https://www.ebi.ac.uk/pdbsum/1qz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qz2 ProSAT]</span></td></tr>
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{{STRUCTURE_1qz2| PDB=1qz2 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FKBP4_HUMAN FKBP4_HUMAN] Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.<ref>PMID:1279700</ref> <ref>PMID:1376003</ref> <ref>PMID:2378870</ref> <ref>PMID:19945390</ref> <ref>PMID:21730050</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qz/1qz2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qz2 ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90===
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==See Also==
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*[[FKBP 3D structures|FKBP 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 15159550 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_15159550}}
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==About this Structure==
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1QZ2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ2 OCA].
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==Reference==
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3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex., Wu B, Li P, Liu Y, Lou Z, Ding Y, Shu C, Ye S, Bartlam M, Shen B, Rao Z, Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8348-53. Epub 2004 May 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15159550 15159550]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Large Structures]]
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[[Category: Protein complex]]
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[[Category: Ding Y]]
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[[Category: Ding, Y.]]
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[[Category: Li P]]
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[[Category: Li, P.]]
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[[Category: Liu Y]]
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[[Category: Liu, Y.]]
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[[Category: Lou Z]]
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[[Category: Lou, Z.]]
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[[Category: Rao Z]]
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[[Category: Rao, Z.]]
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[[Category: Shen B]]
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[[Category: Shen, B.]]
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[[Category: Shu C]]
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[[Category: Shu, C.]]
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[[Category: Wu B]]
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[[Category: Wu, B.]]
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[[Category: Chaperone]]
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[[Category: Heat shock]]
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[[Category: Isomerase]]
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[[Category: Rotamase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:46:59 2008''
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Current revision

Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90

PDB ID 1qz2

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