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1ri7

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[[Image:1ri7.jpg|left|200px]]
 
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==crystal structure of a protein in the LRP/ASNC family from the hyperthermophilic archaeon Pyrococcus sp. OT3==
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The line below this paragraph, containing "STRUCTURE_1ri7", creates the "Structure Box" on the page.
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<StructureSection load='1ri7' size='340' side='right'caption='[[1ri7]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ri7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RI7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RI7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ri7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ri7 OCA], [https://pdbe.org/1ri7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ri7 RCSB], [https://www.ebi.ac.uk/pdbsum/1ri7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ri7 ProSAT]</span></td></tr>
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{{STRUCTURE_1ri7| PDB=1ri7 | SCENE= }}
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</table>
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== Function ==
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'''crystal structure of a protein in the LRP/ASNC family from the hyperthermophilic archaeon Pyrococcus sp. OT3'''
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[https://www.uniprot.org/uniprot/REG6_PYRHO REG6_PYRHO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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The classification feast/famine regulatory proteins (FFRPs) encompasses archaeal DNA-binding proteins with Escherichia coli transcription factors, the leucine-responsive regulatory protein and the asparagine synthase C gene product. In this paper, we describe two forms of the archaeal FFRP FL11 (pot0434017), both assembled from dimers. When crystallized, a helical cylinder is formed with six dimers per turn. In contrast, in solution, disks are formed, most likely consisting of four dimers each; an observation by cryoelectron microscopy. Whereas each dimer binds a 13-bp sequence, different forms will discriminate between promoters, based on the numbers of repeating 13-bp sequences, and types of linkers inserted between them, which are either of 7-8 or approximately 18 bp. The amino acid sequences of these FFRPs are designed to form the same type of 3D structures, and the transition between their assembly forms is regulated by interaction with small molecules. These considerations lead us to propose a possible mechanism for regulating a number of genes by varying assembly forms and by combining different FFRPs into these assemblies, responding to environmental changes.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ri/1ri7_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1RI7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_sp. Pyrococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RI7 OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ri7 ConSurf].
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The archaeal feast/famine regulatory protein: potential roles of its assembly forms for regulating transcription., Koike H, Ishijima SA, Clowney L, Suzuki M, Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2840-5. Epub 2004 Feb 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14976242 14976242]
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<div style="clear:both"></div>
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[[Category: Pyrococcus sp.]]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Koike, H.]]
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[[Category: Large Structures]]
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[[Category: Suzuki, M.]]
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[[Category: Pyrococcus horikoshii OT3]]
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[[Category: Lrp/asnc family]]
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[[Category: Koike H]]
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[[Category: Transcription]]
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[[Category: Suzuki M]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:31:43 2008''
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Current revision

crystal structure of a protein in the LRP/ASNC family from the hyperthermophilic archaeon Pyrococcus sp. OT3

PDB ID 1ri7

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