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1rxc

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{{Seed}}
 
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[[Image:1rxc.png|left|200px]]
 
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==E. COLI uridine phosphorylase: 5-fluorouracil ribose-1-phosphate complex==
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The line below this paragraph, containing "STRUCTURE_1rxc", creates the "Structure Box" on the page.
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<StructureSection load='1rxc' size='340' side='right'caption='[[1rxc]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1rxc]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RXC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5UD:5-FLUOROURIDINE'>5UD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=R1P:RIBOSE-1-PHOSPHATE'>R1P</scene>, <scene name='pdbligand=URF:5-FLUOROURACIL'>URF</scene></td></tr>
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{{STRUCTURE_1rxc| PDB=1rxc | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxc OCA], [https://pdbe.org/1rxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rxc RCSB], [https://www.ebi.ac.uk/pdbsum/1rxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rxc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UDP_ECOLI UDP_ECOLI] Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rx/1rxc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rxc ConSurf].
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<div style="clear:both"></div>
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===E. COLI uridine phosphorylase: 5-fluorouracil ribose-1-phosphate complex===
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==See Also==
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*[[Uridine phosphorylase 3D structures|Uridine phosphorylase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_15003451}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15003451 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15003451}}
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==About this Structure==
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1RXC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXC OCA].
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==Reference==
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Crystal structures of Escherichia coli uridine phosphorylase in two native and three complexed forms reveal basis of substrate specificity, induced conformational changes and influence of potassium., Caradoc-Davies TT, Cutfield SM, Lamont IL, Cutfield JF, J Mol Biol. 2004 Mar 19;337(2):337-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15003451 15003451]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Uridine phosphorylase]]
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[[Category: Caradoc-Davies TT]]
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[[Category: Caradoc-Davies, T T.]]
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[[Category: Cutfield JF]]
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[[Category: Cutfield, J F.]]
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[[Category: Cutfield SM]]
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[[Category: Cutfield, S M.]]
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[[Category: Lamont IL]]
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[[Category: Lamont, I L.]]
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[[Category: 5-fluorouracil]]
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[[Category: Induced fit]]
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[[Category: Pentosyltransferase]]
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[[Category: Potassium]]
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[[Category: Specificity]]
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[[Category: Uridine phosphorylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:00:35 2008''
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Current revision

E. COLI uridine phosphorylase: 5-fluorouracil ribose-1-phosphate complex

PDB ID 1rxc

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