1t3y

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[[Image:1t3y.gif|left|200px]]
 
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{{Structure
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==Three Crystal Structures of Human Coactosin-like Protein==
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|PDB= 1t3y |SIZE=350|CAPTION= <scene name='initialview01'>1t3y</scene>, resolution 1.15&Aring;
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<StructureSection load='1t3y' size='340' side='right'caption='[[1t3y]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1t3y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T3Y FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3y OCA], [https://pdbe.org/1t3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t3y RCSB], [https://www.ebi.ac.uk/pdbsum/1t3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t3y ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''Three Crystal Structures of Human Coactosin-like Protein'''
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[https://www.uniprot.org/uniprot/COTL1_HUMAN COTL1_HUMAN] Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization.<ref>PMID:11583571</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Disease==
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Check<jmol>
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Known disease associated with this structure: Cardiomyopathy, dilated, 1M OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600824 600824]]
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t3/1t3y_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1T3Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3Y OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t3y ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Chen, Z.]]
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[[Category: Chen Z]]
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[[Category: Liu, L.]]
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[[Category: Liu L]]
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[[Category: Wang, Y.]]
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[[Category: Wang Y]]
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[[Category: Wei, Z.]]
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[[Category: Wei Z]]
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[[Category: beta sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:13:26 2008''
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Current revision

Three Crystal Structures of Human Coactosin-like Protein

PDB ID 1t3y

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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