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1tow

From Proteopedia

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{{Seed}}
 
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[[Image:1tow.png|left|200px]]
 
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<!--
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==Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand==
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The line below this paragraph, containing "STRUCTURE_1tow", creates the "Structure Box" on the page.
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<StructureSection load='1tow' size='340' side='right'caption='[[1tow]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tow]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TOW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CRZ:4-(9H-CARBAZOL-9-YL)BUTANOIC+ACID'>CRZ</scene></td></tr>
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{{STRUCTURE_1tow| PDB=1tow | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tow OCA], [https://pdbe.org/1tow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tow RCSB], [https://www.ebi.ac.uk/pdbsum/1tow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tow ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/to/1tow_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tow ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand===
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==See Also==
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*[[Fatty acid-binding protein 3D structures|Fatty acid-binding protein 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_15357969}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15357969 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15357969}}
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==About this Structure==
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1TOW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TOW OCA].
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==Reference==
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Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target., Lehmann F, Haile S, Axen E, Medina C, Uppenberg J, Svensson S, Lundback T, Rondahl L, Barf T, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15357969 15357969]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Axen, E.]]
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[[Category: Axen E]]
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[[Category: Barf, T.]]
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[[Category: Barf T]]
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[[Category: Haile, S.]]
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[[Category: Haile S]]
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[[Category: Lehmann, F.]]
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[[Category: Lehmann F]]
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[[Category: Lundback, T.]]
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[[Category: Lundback T]]
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[[Category: Medina, C.]]
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[[Category: Medina C]]
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[[Category: Rondahl, L.]]
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[[Category: Rondahl L]]
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[[Category: Svensson, S.]]
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[[Category: Svensson S]]
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[[Category: Uppenberg, J.]]
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[[Category: Uppenberg J]]
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[[Category: Lipid-binding]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:01:37 2008''
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Current revision

Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand

PDB ID 1tow

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