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1wlz
From Proteopedia
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| - | [[Image:1wlz.png|left|200px]] | ||
| - | + | ==Crystal structure of DJBP fragment which was obtained by limited proteolysis== | |
| - | + | <StructureSection load='1wlz' size='340' side='right'caption='[[1wlz]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1wlz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WLZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wlz OCA], [https://pdbe.org/1wlz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wlz RCSB], [https://www.ebi.ac.uk/pdbsum/1wlz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wlz ProSAT]</span></td></tr> |
| - | [[1wlz]] is a 4 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/EFCB6_HUMAN EFCB6_HUMAN] Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex.<ref>PMID:12612053</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wl/1wlz_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wlz ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Ariga | + | [[Category: Large Structures]] |
| - | [[Category: Honbou | + | [[Category: Ariga H]] |
| - | [[Category: Horiuchi | + | [[Category: Honbou K]] |
| - | [[Category: Inagaki | + | [[Category: Horiuchi M]] |
| - | [[Category: Niki | + | [[Category: Inagaki F]] |
| - | [[Category: Suzuki | + | [[Category: Niki T]] |
| - | [[Category: Taira | + | [[Category: Suzuki N]] |
| - | + | [[Category: Taira T]] | |
| - | + | ||
Current revision
Crystal structure of DJBP fragment which was obtained by limited proteolysis
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Categories: Homo sapiens | Large Structures | Ariga H | Honbou K | Horiuchi M | Inagaki F | Niki T | Suzuki N | Taira T
