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1wn0

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[[Image:1wn0.gif|left|200px]]<br /><applet load="1wn0" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1wn0, resolution 2.20&Aring;" />
 
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'''Crystal Structure of Histidine-containing Phosphotransfer Protein, ZmHP2, from maize'''<br />
 
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==Overview==
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==Crystal Structure of Histidine-containing Phosphotransfer Protein, ZmHP2, from maize==
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In higher plants, histidine-aspartate phosphorelays (two-component system), are involved in hormone signaling and stress responses. In these systems, histidine-containing phosphotransfer (HPt) proteins mediate the signal, transmission from sensory histidine kinases to response regulators, including integration of several signaling pathways or branching into, different pathways. We have determined the crystal structure of a maize, HPt protein, ZmHP2, at 2.2 A resolution. ZmHP2 has six alpha-helices with, a four-helix bundle at the C-terminus, a feature commonly found in HPt, domains. In ZmHP2, almost all of the conserved residues among plant HPt, proteins surround this histidine, probably forming the docking interface, for the receiver domain of histidine kinase or the response regulator., Arg102 of ZmHP2 is conserved as a basic residue in plant HPt proteins. In, bacteria, it is replaced by glutamine or glutamate that form a hydrogen, bond to Ndelta atoms of the phospho-accepting histidine. It may play a key, role in the complex formation of ZmHP2 with receiver domains.
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<StructureSection load='1wn0' size='340' side='right'caption='[[1wn0]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1wn0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Zea_mays Zea mays]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WN0 FirstGlance]. <br>
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1WN0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Zea_mays Zea mays]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN0 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wn0 OCA], [https://pdbe.org/1wn0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wn0 RCSB], [https://www.ebi.ac.uk/pdbsum/1wn0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wn0 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wn0 TOPSAN]</span></td></tr>
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==Reference==
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</table>
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Crystal structure of the histidine-containing phosphotransfer protein ZmHP2 from maize., Sugawara H, Kawano Y, Hatakeyama T, Yamaya T, Kamiya N, Sakakibara H, Protein Sci. 2005 Jan;14(1):202-8. Epub 2004 Dec 2. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15576555 15576555]
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== Function ==
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[[Category: Single protein]]
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[https://www.uniprot.org/uniprot/Q9SLX1_MAIZE Q9SLX1_MAIZE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wn/1wn0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wn0 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Zea mays]]
[[Category: Zea mays]]
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[[Category: Hatakeyama, T.]]
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[[Category: Hatakeyama T]]
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[[Category: Kamiya, N.]]
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[[Category: Kamiya N]]
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[[Category: Kawano, Y.]]
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[[Category: Kawano Y]]
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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[[Category: Sakakibara H]]
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[[Category: Sakakibara, H.]]
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[[Category: Sugawara H]]
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[[Category: Sugawara, H.]]
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[[Category: Yamaya T]]
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[[Category: Yamaya, T.]]
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[[Category: four-helix bundle]]
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[[Category: national project on protein structural and functional analyses]]
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[[Category: nppsfa]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: signaling protein]]
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[[Category: structural genomics]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:55:22 2008''
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Current revision

Crystal Structure of Histidine-containing Phosphotransfer Protein, ZmHP2, from maize

PDB ID 1wn0

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