This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1wnh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1wnh" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wnh, resolution 1.83&Aring;" /> '''Crystal structure of...)
Current revision (13:32, 13 March 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1wnh.gif|left|200px]]<br /><applet load="1wnh" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1wnh, resolution 1.83&Aring;" />
 
-
'''Crystal structure of mouse Latexin (tissue carboxypeptidase inhibitor)'''<br />
 
-
==Overview==
+
==Crystal structure of mouse Latexin (tissue carboxypeptidase inhibitor)==
-
Latexin, the only known mammalian carboxypeptidase inhibitor, has no, detectable sequence similarity with plant and parasite inhibitors, but it, is related to a human putative tumor suppressor protein, TIG1. Latexin is, expressed in the developing brain, and we find that it plays a role in, inflammation, as it is expressed at high levels and is inducible in, macrophages in concert with other protease inhibitors and potential, protease targets. The crystal structure of mouse latexin, solved at 1.83 A, resolution, shows no structural relationship with other carboxypeptidase, inhibitors. Furthermore, despite a lack of detectable sequence, duplication, the structure incorporates two topologically analogous, domains related by pseudo two-fold symmetry. Surprisingly, these domains, share a cystatin fold architecture found in proteins that inhibit cysteine, proteases, suggesting an evolutionary and possibly functional, relationship. The structure of the tumor suppressor protein TIG1 was, modeled, revealing its putative membrane binding surface.
+
<StructureSection load='1wnh' size='340' side='right'caption='[[1wnh]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[1wnh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WNH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WNH FirstGlance]. <br>
-
1WNH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1WNH OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wnh OCA], [https://pdbe.org/1wnh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wnh RCSB], [https://www.ebi.ac.uk/pdbsum/1wnh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wnh ProSAT]</span></td></tr>
-
==Reference==
+
</table>
-
An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to cystatins and the tumor suppressor TIG1., Aagaard A, Listwan P, Cowieson N, Huber T, Ravasi T, Wells CA, Flanagan JU, Kellie S, Hume DA, Kobe B, Martin JL, Structure. 2005 Feb;13(2):309-17. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15698574 15698574]
+
== Function ==
 +
[https://www.uniprot.org/uniprot/LXN_MOUSE LXN_MOUSE] Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4 (By similarity). May play a role in inflammation.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wn/1wnh_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wnh ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Single protein]]
+
[[Category: Aagaard A]]
-
[[Category: Aagaard, A.]]
+
[[Category: Cowieson N]]
-
[[Category: Cowieson, N.]]
+
[[Category: Flanagan JU]]
-
[[Category: Flanagan, J.U.]]
+
[[Category: Huber T]]
-
[[Category: Huber, T.]]
+
[[Category: Hume DA]]
-
[[Category: Hume, D.A.]]
+
[[Category: Kobe B]]
-
[[Category: Kobe, B.]]
+
[[Category: Listwan P]]
-
[[Category: Listwan, P.]]
+
[[Category: Martin JL]]
-
[[Category: Martin, J.L.]]
+
[[Category: Ravasi T]]
-
[[Category: Ravasi, T.]]
+
[[Category: Wells CA]]
-
[[Category: Wells, C.A.]]
+
-
[[Category: bi-cystatin fold]]
+
-
[[Category: cis-proline]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 05:32:53 2007''
+

Current revision

Crystal structure of mouse Latexin (tissue carboxypeptidase inhibitor)

PDB ID 1wnh

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wnh"
Personal tools