This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ww5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1ww5" [edit=sysop:move=sysop])
Current revision (13:34, 13 March 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1ww5.png|left|200px]]
 
-
{{STRUCTURE_1ww5| PDB=1ww5 | SCENE= }}
+
==Agrocybe cylindracea galectin complexed with 3'-sulfonyl lactose==
-
 
+
<StructureSection load='1ww5' size='340' side='right'caption='[[1ww5]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-
===Agrocybe cylindracea galectin complexed with 3'-sulfonyl lactose===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1ww5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrocybe_cylindracea Agrocybe cylindracea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WW5 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_16051274}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=PRD_900068:lactose-3-sulfate'>PRD_900068</scene>, <scene name='pdbligand=SGA:O3-SULFONYLGALACTOSE'>SGA</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ww5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ww5 OCA], [https://pdbe.org/1ww5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ww5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ww5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ww5 ProSAT]</span></td></tr>
-
[[1ww5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrocybe_cylindracea Agrocybe cylindracea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WW5 OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ATLE_CYCAE ATLE_CYCAE] Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells. Binds N-acetylneuraminyl lactose (N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose) (PubMed:16051274).<ref>PMID:12757412</ref> <ref>PMID:16051274</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ww/1ww5_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ww5 ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Galectin|Galectin]]
+
*[[Galectin 3D structures|Galectin 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:016051274</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Agrocybe cylindracea]]
[[Category: Agrocybe cylindracea]]
-
[[Category: Ban, M.]]
+
[[Category: Large Structures]]
-
[[Category: Demirkan, E.]]
+
[[Category: Ban M]]
-
[[Category: Mikami, B.]]
+
[[Category: Demirkan E]]
-
[[Category: Utsumi, S.]]
+
[[Category: Mikami B]]
-
[[Category: Yagi, F.]]
+
[[Category: Utsumi S]]
-
[[Category: Yoon, H J.]]
+
[[Category: Yagi F]]
-
[[Category: 3'-sulfated lactose]]
+
[[Category: Yoon HJ]]
-
[[Category: Agrocybe cylindracea galectin]]
+
-
[[Category: Carbohydrate recognition domain]]
+
-
[[Category: Fungal galectin]]
+
-
[[Category: Sugar binding protein]]
+
-
[[Category: X-ray crystallographic analysis]]
+

Current revision

Agrocybe cylindracea galectin complexed with 3'-sulfonyl lactose

PDB ID 1ww5

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ww5"
Personal tools