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1wzw

From Proteopedia

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[[Image:1wzw.gif|left|200px]]
 
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{{Structure
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==Crystal Structure of UbcH8==
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|PDB= 1wzw |SIZE=350|CAPTION= <scene name='initialview01'>1wzw</scene>, resolution 2.40&Aring;
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<StructureSection load='1wzw' size='340' side='right'caption='[[1wzw]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1wzw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WZW FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wzw OCA], [https://pdbe.org/1wzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wzw RCSB], [https://www.ebi.ac.uk/pdbsum/1wzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wzw ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UB2L6_HUMAN UB2L6_HUMAN] Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.<ref>PMID:15131269</ref> <ref>PMID:16428300</ref> <ref>PMID:20508617</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wz/1wzw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wzw ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of UbcH8'''
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==See Also==
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*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]]
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== References ==
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==About this Structure==
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<references/>
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1WZW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZW OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ubiquitin--protein ligase]]
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[[Category: Mizushima T]]
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[[Category: Mizushima, T.]]
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[[Category: Murata S]]
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[[Category: Murata, S.]]
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[[Category: Suzuki M]]
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[[Category: Suzuki, M.]]
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[[Category: Tanaka K]]
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[[Category: Tanaka, K.]]
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[[Category: Teshima N]]
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[[Category: Teshima, N.]]
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[[Category: Yamane T]]
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[[Category: Yamane, T.]]
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[[Category: e2]]
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[[Category: ubiquitin]]
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[[Category: ubiquitin conjugating enzyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:03:33 2008''
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Current revision

Crystal Structure of UbcH8

PDB ID 1wzw

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OCA

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