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1xse

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{{Seed}}
 
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[[Image:1xse.png|left|200px]]
 
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==Crystal Structure of Guinea Pig 11beta-Hydroxysteroid Dehydrogenase Type 1==
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The line below this paragraph, containing "STRUCTURE_1xse", creates the "Structure Box" on the page.
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<StructureSection load='1xse' size='340' side='right'caption='[[1xse]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1xse]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cavia_porcellus Cavia porcellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XSE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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{{STRUCTURE_1xse| PDB=1xse | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xse OCA], [https://pdbe.org/1xse PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xse RCSB], [https://www.ebi.ac.uk/pdbsum/1xse PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xse ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DHI1_CAVPO DHI1_CAVPO] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).<ref>PMID:10699594</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xs/1xse_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xse ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of Guinea Pig 11beta-Hydroxysteroid Dehydrogenase Type 1===
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==See Also==
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*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_15542590}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 15542590 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_15542590}}
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==About this Structure==
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1XSE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Cavia_porcellus Cavia porcellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSE OCA].
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==Reference==
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The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions., Ogg D, Elleby B, Norstrom C, Stefansson K, Abrahmsen L, Oppermann U, Svensson S, J Biol Chem. 2005 Feb 4;280(5):3789-94. Epub 2004 Nov 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15542590 15542590]
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[[Category: 11-beta-hydroxysteroid dehydrogenase]]
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[[Category: Cavia porcellus]]
[[Category: Cavia porcellus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Abrahmsen, L.]]
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[[Category: Abrahmsen L]]
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[[Category: Elleby, B.]]
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[[Category: Elleby B]]
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[[Category: Norstrom, C.]]
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[[Category: Norstrom C]]
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[[Category: Ogg, D.]]
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[[Category: Ogg D]]
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[[Category: Oppermann, U.]]
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[[Category: Oppermann U]]
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[[Category: Stefansson, K.]]
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[[Category: Stefansson K]]
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[[Category: Svensson, S.]]
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[[Category: Svensson S]]
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[[Category: 11beta-hydroxysteroid dehydrogenase dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:57:56 2008''
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Current revision

Crystal Structure of Guinea Pig 11beta-Hydroxysteroid Dehydrogenase Type 1

PDB ID 1xse

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