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1y2v

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{{Seed}}
 
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[[Image:1y2v.png|left|200px]]
 
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<!--
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==Crystal structure of the common edible mushroom (Agaricus bisporus) lectin in complex with T-antigen==
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The line below this paragraph, containing "STRUCTURE_1y2v", creates the "Structure Box" on the page.
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<StructureSection load='1y2v' size='340' side='right'caption='[[1y2v]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1y2v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Agaricus_bisporus Agaricus bisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y2V FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene></td></tr>
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{{STRUCTURE_1y2v| PDB=1y2v | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2v OCA], [https://pdbe.org/1y2v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y2v RCSB], [https://www.ebi.ac.uk/pdbsum/1y2v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y2v ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the common edible mushroom (Agaricus bisporus) lectin in complex with T-antigen===
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== Function ==
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[https://www.uniprot.org/uniprot/ABL_AGABI ABL_AGABI] Lectin that recognizes O-linked galactose-beta-1,3-N-acetylgalactosamine, a disaccharide (Thomsen-Friedenreich antigen or T-disaccharide), present on cell surface glycoproteins. Can also bind galactose-beta-1,3-N-acetylglucosamine. Does not bind monosaccharides. Can be internalized by clathrin-coated vesicles after binding to surface glycoproteins. After internalization it inhibits nuclear import of nuclear localization signal dependent proteins. Inhibits proliferation of malignant cells without cytotoxicity for normal cells.<ref>PMID:4343164</ref> <ref>PMID:8402638</ref> <ref>PMID:9988731</ref>
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_15596442}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 15596442 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y2/1y2v_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_15596442}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1Y2V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Agaricus_bisporus Agaricus bisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2V OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y2v ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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The antineoplastic lectin of the common edible mushroom (Agaricus bisporus) has two binding sites, each specific for a different configuration at a single epimeric hydroxyl., Carrizo ME, Capaldi S, Perduca M, Irazoqui FJ, Nores GA, Monaco HL, J Biol Chem. 2005 Mar 18;280(11):10614-23. Epub 2004 Dec 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15596442 15596442]
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<references/>
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__TOC__
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Crystallization and preliminary X-ray study of the common edible mushroom (Agaricus bisporus) lectin., Carrizo ME, Irazoqui FJ, Lardone RD, Nores GA, Curtino JA, Capaldi S, Perduca M, Monaco HL, Acta Crystallogr D Biol Crystallogr. 2004 Apr;60(Pt 4):718-20. Epub 2004, Mar 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15039564 15039564]
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</StructureSection>
[[Category: Agaricus bisporus]]
[[Category: Agaricus bisporus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Capaldi, S.]]
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[[Category: Capaldi S]]
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[[Category: Carrizo, M E.]]
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[[Category: Carrizo ME]]
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[[Category: Irazoqui, F J.]]
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[[Category: Irazoqui FJ]]
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[[Category: Monaco, H L.]]
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[[Category: Monaco HL]]
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[[Category: Nores, G A.]]
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[[Category: Nores GA]]
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[[Category: Perduca, M.]]
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[[Category: Perduca M]]
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[[Category: Abl]]
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[[Category: Agaricus bisporus]]
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[[Category: Lectin]]
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[[Category: Mushroom]]
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[[Category: T-antigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:32:55 2008''
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Current revision

Crystal structure of the common edible mushroom (Agaricus bisporus) lectin in complex with T-antigen

PDB ID 1y2v

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