1ym5

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[[Image:1ym5.gif|left|200px]]
 
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{{Structure
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==Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily.==
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|PDB= 1ym5 |SIZE=350|CAPTION= <scene name='initialview01'>1ym5</scene>, resolution 2.05&Aring;
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<StructureSection load='1ym5' size='340' side='right'caption='[[1ym5]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1ym5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YM5 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ym5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ym5 OCA], [https://pdbe.org/1ym5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ym5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ym5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ym5 ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ym5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ym5 OCA], [http://www.ebi.ac.uk/pdbsum/1ym5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ym5 RCSB]</span>
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[https://www.uniprot.org/uniprot/YHI9_YEAST YHI9_YEAST]
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily.'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ym/1ym5_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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In the Pseudomonas bacterial genomes, the PhzF proteins are involved in the production of phenazine derivative antibiotic and antifungal compounds. The PhzF superfamily however also encompasses proteins in all genomes from bacteria to eukaryotes, for which no function has been assigned. We have determined the three dimensional crystal structure at 2.05 A resolution of YHI9, the yeast member of the PhzF family. YHI9 has a fold similar to bacterial diaminopimelate epimerase, revealing a bimodular structure with an internal symmetry. Residue conservation identifies a putative active site at the interface between the two domains. Evolution of this protein by gene duplication, gene fusion and domain swapping from an ancestral gene containing the "hot dog" fold, identifies the protein as a "kinked double hot dog" fold.
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ym5 ConSurf].
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1YM5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YM5 OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily., Liger D, Quevillon-Cheruel S, Sorel I, Bremang M, Blondeau K, Aboulfath I, Janin J, van Tilbeurgh H, Leulliot N, Proteins. 2005 Sep 1;60(4):778-86. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16021630 16021630]
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Aboulfath I]]
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[[Category: Aboulfath, I.]]
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[[Category: Blondeau K]]
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[[Category: Blondeau, K.]]
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[[Category: Bremang M]]
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[[Category: Bremang, M.]]
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[[Category: Janin J]]
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[[Category: Janin, J.]]
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[[Category: Leulliot N]]
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[[Category: Leulliot, N.]]
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[[Category: Liger D]]
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[[Category: Liger, D.]]
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[[Category: Quevillon-Cheruel S]]
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[[Category: Quevillon-Cheruel, S.]]
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[[Category: Sorel I]]
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[[Category: Sorel, I.]]
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[[Category: Van Tilbeurgh H]]
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[[Category: Tilbeurgh, H Van.]]
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[[Category: YSG, Paris-Sud Yeast Structural Genomics.]]
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[[Category: double hot-dog]]
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[[Category: paris-sud yeast structural genomic]]
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[[Category: phzf enzyme superfamily]]
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[[Category: structural genomic]]
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[[Category: ysg]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:12:59 2008''
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Current revision

Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily.

PDB ID 1ym5

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