1ym5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1ym5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ym5, resolution 2.05&Aring;" /> '''Crystal structure of...)
Current revision (13:38, 13 March 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1ym5.gif|left|200px]]<br /><applet load="1ym5" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1ym5, resolution 2.05&Aring;" />
 
-
'''Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily.'''<br />
 
-
==Overview==
+
==Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily.==
-
In the Pseudomonas bacterial genomes, the PhzF proteins are involved in, the production of phenazine derivative antibiotic and antifungal, compounds. The PhzF superfamily however also encompasses proteins in all, genomes from bacteria to eukaryotes, for which no function has been, assigned. We have determined the three dimensional crystal structure at, 2.05 A resolution of YHI9, the yeast member of the PhzF family. YHI9 has a, fold similar to bacterial diaminopimelate epimerase, revealing a bimodular, structure with an internal symmetry. Residue conservation identifies a, putative active site at the interface between the two domains. Evolution, of this protein by gene duplication, gene fusion and domain swapping from, an ancestral gene containing the "hot dog" fold, identifies the protein as, a "kinked double hot dog" fold.
+
<StructureSection load='1ym5' size='340' side='right'caption='[[1ym5]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[1ym5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YM5 FirstGlance]. <br>
-
1YM5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1YM5 OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ym5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ym5 OCA], [https://pdbe.org/1ym5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ym5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ym5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ym5 ProSAT]</span></td></tr>
-
==Reference==
+
</table>
-
Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily., Liger D, Quevillon-Cheruel S, Sorel I, Bremang M, Blondeau K, Aboulfath I, Janin J, van Tilbeurgh H, Leulliot N, Proteins. 2005 Sep 1;60(4):778-86. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16021630 16021630]
+
== Function ==
 +
[https://www.uniprot.org/uniprot/YHI9_YEAST YHI9_YEAST]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ym/1ym5_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ym5 ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
-
[[Category: Single protein]]
+
[[Category: Aboulfath I]]
-
[[Category: Aboulfath, I.]]
+
[[Category: Blondeau K]]
-
[[Category: Blondeau, K.]]
+
[[Category: Bremang M]]
-
[[Category: Bremang, M.]]
+
[[Category: Janin J]]
-
[[Category: Janin, J.]]
+
[[Category: Leulliot N]]
-
[[Category: Leulliot, N.]]
+
[[Category: Liger D]]
-
[[Category: Liger, D.]]
+
[[Category: Quevillon-Cheruel S]]
-
[[Category: Quevillon-Cheruel, S.]]
+
[[Category: Sorel I]]
-
[[Category: Sorel, I.]]
+
[[Category: Van Tilbeurgh H]]
-
[[Category: Tilbeurgh, H.Van.]]
+
-
[[Category: YSG, Paris-Sud.Yeast.Structural.Genomics.]]
+
-
[[Category: double hot-dog]]
+
-
[[Category: paris-sud yeast structural genomics]]
+
-
[[Category: phzf enzyme superfamily]]
+
-
[[Category: structural genomics]]
+
-
[[Category: ysg]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 06:54:12 2007''
+

Current revision

Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily.

PDB ID 1ym5

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ym5"
Personal tools