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1z0m

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{{Seed}}
 
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[[Image:1z0m.png|left|200px]]
 
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==the glycogen-binding domain of the AMP-activated protein kinase beta1 subunit==
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The line below this paragraph, containing "STRUCTURE_1z0m", creates the "Structure Box" on the page.
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<StructureSection load='1z0m' size='340' side='right'caption='[[1z0m]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1z0m]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z0M FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900012:beta-cyclodextrin'>PRD_900012</scene></td></tr>
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{{STRUCTURE_1z0m| PDB=1z0m | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z0m OCA], [https://pdbe.org/1z0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z0m RCSB], [https://www.ebi.ac.uk/pdbsum/1z0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z0m ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AAKB1_RAT AAKB1_RAT] Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z0/1z0m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z0m ConSurf].
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<div style="clear:both"></div>
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===the glycogen-binding domain of the AMP-activated protein kinase beta1 subunit===
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==See Also==
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*[[AMP-activated protein kinase 3D structures|AMP-activated protein kinase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_16216577}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16216577 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16216577}}
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==About this Structure==
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1Z0M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z0M OCA].
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==Reference==
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Structural basis for glycogen recognition by AMP-activated protein kinase., Polekhina G, Gupta A, van Denderen BJ, Feil SC, Kemp BE, Stapleton D, Parker MW, Structure. 2005 Oct;13(10):1453-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16216577 16216577]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Feil SC]]
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[[Category: Denderen, B J.van.]]
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[[Category: Gupta A]]
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[[Category: Feil, S C.]]
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[[Category: Kemp BE]]
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[[Category: Gupta, A.]]
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[[Category: Parker MW]]
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[[Category: Kemp, B E.]]
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[[Category: Polekhina G]]
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[[Category: Parker, M W.]]
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[[Category: Stapleton D]]
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[[Category: Polekhina, G.]]
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[[Category: Van Denderen BJ]]
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[[Category: Stapleton, D.]]
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[[Category: Beta sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:54:16 2008''
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Current revision

the glycogen-binding domain of the AMP-activated protein kinase beta1 subunit

PDB ID 1z0m

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