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1zcd
From Proteopedia
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| - | {{STRUCTURE_1zcd| PDB=1zcd | SCENE= }} | ||
| - | ===Crystal structure of the Na+/H+ antiporter NhaA=== | ||
| - | {{ABSTRACT_PUBMED_15988517}} | ||
| - | == | + | ==Crystal structure of the Na+/H+ antiporter NhaA== |
| - | [[ | + | <StructureSection load='1zcd' size='340' side='right'caption='[[1zcd]], [[Resolution|resolution]] 3.45Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[1zcd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The December 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Complex I'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_12 10.2210/rcsb_pdb/mom_2011_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZCD FirstGlance]. <br> |
| - | [[1zcd]] is a 2 chain structure with sequence from [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.45Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zcd OCA], [https://pdbe.org/1zcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zcd RCSB], [https://www.ebi.ac.uk/pdbsum/1zcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zcd ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | < | + | == Function == |
| + | [https://www.uniprot.org/uniprot/NHAA_ECOLI NHAA_ECOLI] Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Catalyzes the exchange of 2 H(+) per Na(+). Can mediate sodium uptake when a transmembrane pH gradient is applied. Active at alkaline pH. Activity is strongly down-regulated below pH 6.5.<ref>PMID:1645730</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zc/1zcd_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zcd ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Complex I]] | [[Category: Complex I]] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
| - | [[Category: Hunte | + | [[Category: Hunte C]] |
| - | [[Category: Michel | + | [[Category: Michel H]] |
| - | [[Category: Padan | + | [[Category: Padan E]] |
| - | [[Category: Rimon | + | [[Category: Rimon A]] |
| - | [[Category: Screpanti | + | [[Category: Screpanti E]] |
| - | [[Category: Venturi | + | [[Category: Venturi M]] |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of the Na+/H+ antiporter NhaA
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