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1zzw

From Proteopedia

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[[Image:1zzw.png|left|200px]]
 
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{{STRUCTURE_1zzw| PDB=1zzw | SCENE= }}
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==Crystal Structure of catalytic domain of Human MAP Kinase Phosphatase 5==
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<StructureSection load='1zzw' size='340' side='right'caption='[[1zzw]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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===Crystal Structure of catalytic domain of Human MAP Kinase Phosphatase 5===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1zzw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZZW FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16806267}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zzw OCA], [https://pdbe.org/1zzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zzw RCSB], [https://www.ebi.ac.uk/pdbsum/1zzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zzw ProSAT]</span></td></tr>
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[[1zzw]] is a 2 chain structure of [[MAP kinase phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZW OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DUS10_HUMAN DUS10_HUMAN] Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily.<ref>PMID:22375048</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zz/1zzw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zzw ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[MAP kinase phosphatase|MAP kinase phosphatase]]
*[[MAP kinase phosphatase|MAP kinase phosphatase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016806267</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Jeong, D G.]]
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[[Category: Large Structures]]
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[[Category: Jeong, S K.]]
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[[Category: Jeong DG]]
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[[Category: Kim, J H.]]
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[[Category: Jeong SK]]
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[[Category: Kim, S J.]]
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[[Category: Kim JH]]
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[[Category: Ryu, S E.]]
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[[Category: Kim SJ]]
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[[Category: Shim, M Y.]]
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[[Category: Ryu SE]]
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[[Category: Son, J H.]]
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[[Category: Shim MY]]
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[[Category: Yoon, T S.]]
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[[Category: Son JH]]
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[[Category: Hydrolase]]
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[[Category: Yoon TS]]
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[[Category: Mkp]]
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[[Category: Phosphatase]]
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[[Category: Ptp]]
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Current revision

Crystal Structure of catalytic domain of Human MAP Kinase Phosphatase 5

PDB ID 1zzw

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