2ac3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:40, 13 March 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2ac3.gif|left|200px]]
 
-
{{Structure
+
==Structure of human Mnk2 Kinase Domain==
-
|PDB= 2ac3 |SIZE=350|CAPTION= <scene name='initialview01'>2ac3</scene>, resolution 2.1&Aring;
+
<StructureSection load='2ac3' size='340' side='right'caption='[[2ac3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
<table><tr><td colspan='2'>[[2ac3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AC3 FirstGlance]. <br>
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ac3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ac3 OCA], [https://pdbe.org/2ac3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ac3 RCSB], [https://www.ebi.ac.uk/pdbsum/2ac3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ac3 ProSAT]</span></td></tr>
-
|RELATEDENTRY=[[2ac5|2AC5]]
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ac3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ac3 OCA], [http://www.ebi.ac.uk/pdbsum/2ac3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ac3 RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/MKNK2_HUMAN MKNK2_HUMAN] Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.<ref>PMID:11154262</ref> <ref>PMID:11463832</ref> <ref>PMID:12897141</ref> <ref>PMID:16111636</ref> <ref>PMID:17965020</ref> <ref>PMID:18299328</ref> <ref>PMID:20823271</ref> <ref>PMID:20927323</ref> <ref>PMID:21149447</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ac/2ac3_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ac3 ConSurf].
 +
<div style="clear:both"></div>
-
'''Structure of human Mnk2 Kinase Domain'''
+
==See Also==
-
 
+
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
2AC3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AC3 OCA].
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Non-specific serine/threonine protein kinase]]
+
[[Category: Large Structures]]
-
[[Category: Single protein]]
+
[[Category: Aicher B]]
-
[[Category: Aicher, B.]]
+
[[Category: Jackle H]]
-
[[Category: Jackle, H.]]
+
[[Category: Jakel S]]
-
[[Category: Jakel, S.]]
+
[[Category: Jauch R]]
-
[[Category: Jauch, R.]]
+
[[Category: Netter C]]
-
[[Category: Netter, C.]]
+
[[Category: Schreiter K]]
-
[[Category: Schreiter, K.]]
+
[[Category: Wahl MC]]
-
[[Category: Wahl, M C.]]
+
-
[[Category: dfd motif]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:50:43 2008''
+

Current revision

Structure of human Mnk2 Kinase Domain

PDB ID 2ac3

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ac3"
Personal tools