We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

2akf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:41, 13 March 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2akf.gif|left|200px]]
 
-
<!--
+
==Crystal structure of the coiled-coil domain of coronin 1==
-
The line below this paragraph, containing "STRUCTURE_2akf", creates the "Structure Box" on the page.
+
<StructureSection load='2akf' size='340' side='right'caption='[[2akf]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2akf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AKF FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
{{STRUCTURE_2akf| PDB=2akf | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2akf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2akf OCA], [https://pdbe.org/2akf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2akf RCSB], [https://www.ebi.ac.uk/pdbsum/2akf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2akf ProSAT]</span></td></tr>
-
 
+
</table>
-
'''Crystal structure of the coiled-coil domain of coronin 1'''
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/COR1A_MOUSE COR1A_MOUSE] May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.<ref>PMID:10338208</ref>
-
 
+
== References ==
-
==Overview==
+
<references/>
-
In recent years, short coiled coils have been used for applications ranging from biomaterial to medical sciences. For many of these applications knowledge of the factors that control the topology of the engineered protein systems is essential. Here, we demonstrate that trimerization of short coiled coils is determined by a distinct structural motif that encompasses specific networks of surface salt bridges and optimal hydrophobic packing interactions. The motif is conserved among intracellular, extracellular, viral, and synthetic proteins and defines a universal molecular determinant for trimer formation of short coiled coils. In addition to being of particular interest for the biotechnological production of candidate therapeutic proteins, these findings may be of interest for viral drug development strategies.
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
2AKF is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AKF OCA].
+
[[Category: Mus musculus]]
-
 
+
[[Category: Avila D]]
-
==Reference==
+
[[Category: Honnappa S]]
-
A conserved trimerization motif controls the topology of short coiled coils., Kammerer RA, Kostrewa D, Progias P, Honnappa S, Avila D, Lustig A, Winkler FK, Pieters J, Steinmetz MO, Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13891-6. Epub 2005 Sep 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16172398 16172398]
+
[[Category: Kammerer RA]]
-
[[Category: Single protein]]
+
[[Category: Kostrewa D]]
-
[[Category: Avila, D.]]
+
[[Category: Lustig A]]
-
[[Category: Honnappa, S.]]
+
[[Category: Pieters J]]
-
[[Category: Kammerer, R A.]]
+
[[Category: Progias P]]
-
[[Category: Kostrewa, D.]]
+
[[Category: Steinmetz MO]]
-
[[Category: Lustig, A.]]
+
[[Category: Winkler FK]]
-
[[Category: Pieters, J.]]
+
-
[[Category: Progias, P.]]
+
-
[[Category: Steinmetz, M O.]]
+
-
[[Category: Winkler, F K.]]
+
-
[[Category: Coiled coil]]
+
-
[[Category: Coronin 1]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:09:25 2008''
+

Current revision

Crystal structure of the coiled-coil domain of coronin 1

PDB ID 2akf

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2akf"
Personal tools