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2cxr

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[[Image:2cxr.png|left|200px]]
 
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{{STRUCTURE_2cxr| PDB=2cxr | SCENE= }}
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==Crystal structure of mouse AMF / 6PG complex==
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<StructureSection load='2cxr' size='340' side='right'caption='[[2cxr]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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===Crystal structure of mouse AMF / 6PG complex===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2cxr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CXR FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16375918}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6PG:6-PHOSPHOGLUCONIC+ACID'>6PG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cxr OCA], [https://pdbe.org/2cxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cxr RCSB], [https://www.ebi.ac.uk/pdbsum/2cxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cxr ProSAT]</span></td></tr>
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[[2cxr]] is a 2 chain structure of [[Phosphoglucose isomerase]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CXR OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/G6PI_MOUSE G6PI_MOUSE] Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/2cxr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cxr ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Phosphoglucoisomerase|Phosphoglucoisomerase]]
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*[[Phosphoglucose isomerase 3D structures|Phosphoglucose isomerase 3D structures]]
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*[[Phosphoglucose isomerase|Phosphoglucose isomerase]]
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Large Structures]]
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<ref group="xtra">PMID:016375918</ref><references group="xtra"/>
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[[Category: Glucose-6-phosphate isomerase]]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Funasaka, T.]]
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[[Category: Funasaka T]]
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[[Category: Haga, A.]]
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[[Category: Haga A]]
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[[Category: Hashimoto, K.]]
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[[Category: Hashimoto K]]
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[[Category: Kusakabe, Y.]]
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[[Category: Kusakabe Y]]
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[[Category: Naba, N.]]
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[[Category: Naba N]]
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[[Category: Nagase, H.]]
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[[Category: Nagase H]]
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[[Category: Nakamura, K T.]]
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[[Category: Nakamura KT]]
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[[Category: Raz, A.]]
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[[Category: Raz A]]
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[[Category: Shiraiwa, K.]]
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[[Category: Shiraiwa K]]
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[[Category: Tanaka, N.]]
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[[Category: Tanaka N]]
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[[Category: Isomerase]]
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Current revision

Crystal structure of mouse AMF / 6PG complex

PDB ID 2cxr

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