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2d1i

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{{Seed}}
 
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[[Image:2d1i.png|left|200px]]
 
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<!--
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==Structure of human Atg4b==
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The line below this paragraph, containing "STRUCTURE_2d1i", creates the "Structure Box" on the page.
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<StructureSection load='2d1i' size='340' side='right'caption='[[2d1i]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2d1i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D1I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D1I FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d1i OCA], [https://pdbe.org/2d1i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d1i RCSB], [https://www.ebi.ac.uk/pdbsum/2d1i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d1i ProSAT]</span></td></tr>
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{{STRUCTURE_2d1i| PDB=2d1i | SCENE= }}
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</table>
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== Function ==
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===Structure of human Atg4b===
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[https://www.uniprot.org/uniprot/ATG4B_HUMAN ATG4B_HUMAN] Cysteine protease required for autophagy, which cleaves the C-terminal part of MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Also mediates the lipid deconjugation required for target recycling.<ref>PMID:15169837</ref> <ref>PMID:19322194</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<!--
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_16325851}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 16325851 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d1/2d1i_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_16325851}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d1i ConSurf].
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2D1I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D1I OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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The crystal structure of human Atg4b, a processing and de-conjugating enzyme for autophagosome-forming modifiers., Kumanomidou T, Mizushima T, Komatsu M, Suzuki A, Tanida I, Sou YS, Ueno T, Kominami E, Tanaka K, Yamane T, J Mol Biol. 2006 Jan 27;355(4):612-8. Epub 2005 Nov 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16325851 16325851]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Komatsu, M.]]
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[[Category: Komatsu M]]
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[[Category: Kominami, E.]]
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[[Category: Kominami E]]
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[[Category: Kumanomidou, T.]]
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[[Category: Kumanomidou T]]
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[[Category: Mizushima, T.]]
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[[Category: Mizushima T]]
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[[Category: Sou, Y S.]]
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[[Category: Sou YS]]
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[[Category: Suzuki, A.]]
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[[Category: Suzuki A]]
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[[Category: Tanaka, K.]]
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[[Category: Tanaka K]]
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[[Category: Tanida, I.]]
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[[Category: Tanida I]]
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[[Category: Ueno, T.]]
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[[Category: Ueno T]]
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[[Category: Yamane, T.]]
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[[Category: Yamane T]]
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[[Category: Apg]]
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[[Category: Atg]]
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[[Category: Autophagy]]
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[[Category: Cysteine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:32:36 2008''
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Current revision

Structure of human Atg4b

PDB ID 2d1i

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