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2d1x

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{{Seed}}
 
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[[Image:2d1x.png|left|200px]]
 
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<!--
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==The crystal structure of the cortactin-SH3 domain and AMAP1-peptide complex==
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The line below this paragraph, containing "STRUCTURE_2d1x", creates the "Structure Box" on the page.
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<StructureSection load='2d1x' size='340' side='right'caption='[[2d1x]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2d1x]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D1X FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2d1x| PDB=2d1x | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d1x OCA], [https://pdbe.org/2d1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d1x RCSB], [https://www.ebi.ac.uk/pdbsum/2d1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d1x ProSAT]</span></td></tr>
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</table>
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===The crystal structure of the cortactin-SH3 domain and AMAP1-peptide complex===
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== Function ==
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[https://www.uniprot.org/uniprot/SRC8_HUMAN SRC8_HUMAN] Contributes to the organization of the actin cytoskeleton and cell structure. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.<ref>PMID:21296879</ref> <ref>PMID:16636290</ref>
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_16636290}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 16636290 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d1/2d1x_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16636290}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2D1X is a 6 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D1X OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d1x ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:16636290</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Agatsuma, T.]]
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[[Category: Large Structures]]
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[[Category: Akagi, K.]]
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[[Category: Agatsuma T]]
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[[Category: Hashimoto, A.]]
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[[Category: Akagi K]]
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[[Category: Hashimoto, S.]]
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[[Category: Hashimoto A]]
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[[Category: Hirose, M.]]
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[[Category: Hashimoto S]]
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[[Category: Hosaka, H.]]
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[[Category: Hirose M]]
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[[Category: Ikegami, T.]]
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[[Category: Hosaka H]]
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[[Category: Kobayashi, H.]]
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[[Category: Ikegami T]]
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[[Category: Morishige, M.]]
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[[Category: Kobayashi H]]
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[[Category: Nakagawa, A.]]
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[[Category: Morishige M]]
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[[Category: Nakano, H.]]
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[[Category: Nakagawa A]]
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[[Category: Ogawa, E.]]
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[[Category: Nakano H]]
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[[Category: Okada, M.]]
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[[Category: Ogawa E]]
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[[Category: Oneyama, C.]]
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[[Category: Okada M]]
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[[Category: Sabe, H.]]
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[[Category: Oneyama C]]
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[[Category: Wada, H.]]
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[[Category: Sabe H]]
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[[Category: Yamada, A.]]
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[[Category: Wada H]]
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[[Category: Cell invasion]]
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[[Category: Yamada A]]
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[[Category: Complex]]
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[[Category: Proline-rich]]
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[[Category: Sh3]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 22 12:12:16 2010''
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Current revision

The crystal structure of the cortactin-SH3 domain and AMAP1-peptide complex

PDB ID 2d1x

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