2dsk

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[[Image:2dsk.jpg|left|200px]]<br /><applet load="2dsk" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2dsk, resolution 1.50&Aring;" />
 
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'''Crystal structure of catalytic domain of hyperthermophilic chitinase from Pyrococcus furiosus'''<br />
 
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==Overview==
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==Crystal structure of catalytic domain of hyperthermophilic chitinase from Pyrococcus furiosus==
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The crystal structure of the catalytic domain of a chitinase from the hyperthermophilic archaeon Pyrococcus furiosus (AD2(PF-ChiA)) has been determined at 1.5 A resolution. This is the first structure of the catalytic domain of an archaeal chitinase. The overall structure of AD2(PF-ChiA) is a TIM-barrel fold with a tunnel-like active site that is a common feature of family 18 chitinases. Although the catalytic residues (Asp522, Asp524 and Glu526) are conserved, comparison of the conserved residues and structures with those of other homologous chitinases indicates that the catalytic mechanism of PF-ChiA is different from that of family 18 chitinases.
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<StructureSection load='2dsk' size='340' side='right'caption='[[2dsk]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2dsk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DSK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dsk OCA], [https://pdbe.org/2dsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dsk RCSB], [https://www.ebi.ac.uk/pdbsum/2dsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dsk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8U1H5_PYRFU Q8U1H5_PYRFU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ds/2dsk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dsk ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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2DSK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSK OCA].
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*[[Chitinase 3D structures|Chitinase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Structure of the catalytic domain of the hyperthermophilic chitinase from Pyrococcus furiosus., Nakamura T, Mine S, Hagihara Y, Ishikawa K, Uegaki K, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jan 1;63(Pt, 1):7-11. Epub 2006 Dec 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17183162 17183162]
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[[Category: Large Structures]]
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[[Category: Chitinase]]
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[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
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[[Category: Single protein]]
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[[Category: Hagihara Y]]
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[[Category: Hagihara, Y.]]
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[[Category: Ishikawa K]]
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[[Category: Ishikawa, K.]]
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[[Category: Mine S]]
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[[Category: Mine, S.]]
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[[Category: Nakamura T]]
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[[Category: Nakamura, T.]]
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[[Category: Uegaki K]]
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[[Category: Uegaki, K.]]
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[[Category: GOL]]
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[[Category: SO4]]
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[[Category: active domain]]
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[[Category: catalytic domain]]
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[[Category: chitinase]]
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[[Category: crystalline chitin]]
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[[Category: tim-barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:02:09 2008''
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Current revision

Crystal structure of catalytic domain of hyperthermophilic chitinase from Pyrococcus furiosus

PDB ID 2dsk

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