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2e3m

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[[Image:2e3m.jpg|left|200px]]<br /><applet load="2e3m" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2e3m, resolution 2.20&Aring;" />
 
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'''Crystal structure of CERT START domain'''<br />
 
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==About this Structure==
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==Crystal structure of CERT START domain==
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2E3M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2E3M OCA].
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<StructureSection load='2e3m' size='340' side='right'caption='[[2e3m]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2e3m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E3M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e3m OCA], [https://pdbe.org/2e3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e3m RCSB], [https://www.ebi.ac.uk/pdbsum/2e3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e3m ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CERT_HUMAN CERT_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/CERT_HUMAN CERT_HUMAN] Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.<ref>PMID:14685229</ref> <ref>PMID:17591919</ref> <ref>PMID:18184806</ref> <ref>PMID:20036255</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e3/2e3m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e3m ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Hanada, K.]]
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[[Category: Hanada K]]
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[[Category: Kato, R.]]
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[[Category: Kato R]]
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[[Category: Kudo, N.]]
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[[Category: Kudo N]]
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[[Category: Kumagai, K.]]
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[[Category: Kumagai K]]
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[[Category: Nishijima, M.]]
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[[Category: Nishijima M]]
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[[Category: Wakatsuki, S.]]
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[[Category: Wakatsuki S]]
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[[Category: ceramide transfer]]
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[[Category: cert]]
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[[Category: lipid transfer protein]]
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[[Category: lipid transport]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Dec 19 11:11:22 2007''
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Current revision

Crystal structure of CERT START domain

PDB ID 2e3m

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