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2ful

From Proteopedia

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[[Image:2ful.png|left|200px]]
 
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{{STRUCTURE_2ful| PDB=2ful | SCENE= }}
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==Crystal Structure of the C-terminal Domain of S. cerevisiae eIF5==
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<StructureSection load='2ful' size='340' side='right'caption='[[2ful]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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===Crystal Structure of the C-terminal Domain of S. cerevisiae eIF5===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ful]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FUL FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16616930}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ful FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ful OCA], [https://pdbe.org/2ful PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ful RCSB], [https://www.ebi.ac.uk/pdbsum/2ful PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ful ProSAT]</span></td></tr>
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[[2ful]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FUL OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IF5_YEAST IF5_YEAST] Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]). eIF-5 is essential for cell viability.<ref>PMID:12651896</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fu/2ful_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ful ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Eukaryotic initiation factor|Eukaryotic initiation factor]]
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*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016616930</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Gong, W.]]
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[[Category: Gong W]]
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[[Category: Wei, Z.]]
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[[Category: Wei Z]]
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[[Category: Xu, H.]]
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[[Category: Xu H]]
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[[Category: Xue, Y.]]
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[[Category: Xue Y]]
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[[Category: Atypical heat motif]]
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[[Category: Translation]]
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Current revision

Crystal Structure of the C-terminal Domain of S. cerevisiae eIF5

PDB ID 2ful

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