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2g62

From Proteopedia

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[[Image:2g62.png|left|200px]]
 
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{{STRUCTURE_2g62| PDB=2g62 | SCENE= }}
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==Crystal structure of human PTPA==
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<StructureSection load='2g62' size='340' side='right'caption='[[2g62]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2g62]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G62 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g62 OCA], [https://pdbe.org/2g62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g62 RCSB], [https://www.ebi.ac.uk/pdbsum/2g62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g62 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTPA_HUMAN PTPA_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.<ref>PMID:17333320</ref> <ref>PMID:16916641</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/2g62_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g62 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human PTPA===
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==See Also==
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*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
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{{ABSTRACT_PUBMED_16782712}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2g62]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G62 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:016782712</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.]]
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[[Category: Large Structures]]
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[[Category: Berg, S Van Den.]]
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[[Category: Arrowsmith C]]
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[[Category: Berglund, H.]]
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[[Category: Berglund H]]
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[[Category: Collins, R.]]
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[[Category: Collins R]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Ehn, M.]]
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[[Category: Ehn M]]
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[[Category: Flodin, S.]]
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[[Category: Flodin S]]
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[[Category: Flores, A.]]
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[[Category: Flores A]]
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[[Category: G Thorsell, A.]]
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[[Category: Graslund S]]
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[[Category: Graslund, S.]]
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[[Category: Hallberg BM]]
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[[Category: Hallberg, B M.]]
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[[Category: Hammarstrom M]]
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[[Category: Hammarstrom, M.]]
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[[Category: Hogbom M]]
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[[Category: Hogbom, M.]]
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[[Category: Holmberg Schiavone L]]
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[[Category: Kotenyova, T.]]
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[[Category: Kotenyova T]]
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[[Category: Magnusdottir, A.]]
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[[Category: Magnusdottir A]]
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[[Category: Nilsson-Ehle, P.]]
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[[Category: Nilsson-Ehle P]]
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[[Category: Nordlund, P.]]
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[[Category: Nordlund P]]
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[[Category: Nyman, T.]]
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[[Category: Nyman T]]
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[[Category: Ogg, D.]]
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[[Category: Ogg D]]
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[[Category: Persson, C.]]
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[[Category: Persson C]]
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[[Category: Sagemark, J.]]
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[[Category: Sagemark J]]
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[[Category: Schiavone, L Holmberg.]]
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[[Category: Stenmark P]]
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[[Category: Stenmark, P.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Thorsell AG]]
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[[Category: Wallden, K.]]
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[[Category: Van Den Berg S]]
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[[Category: Weigelt, J.]]
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[[Category: Wallden K]]
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[[Category: Hydrolase activator]]
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[[Category: Weigelt J]]
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[[Category: Mgc2184]]
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[[Category: Pp2a]]
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[[Category: Ppp2r4]]
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[[Category: Pr53]]
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[[Category: Protein phosphatase 2a]]
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[[Category: Ptpa]]
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Current revision

Crystal structure of human PTPA

PDB ID 2g62

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