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2g62

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{{Seed}}
 
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[[Image:2g62.png|left|200px]]
 
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==Crystal structure of human PTPA==
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The line below this paragraph, containing "STRUCTURE_2g62", creates the "Structure Box" on the page.
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<StructureSection load='2g62' size='340' side='right'caption='[[2g62]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2g62]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G62 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2g62| PDB=2g62 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g62 OCA], [https://pdbe.org/2g62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g62 RCSB], [https://www.ebi.ac.uk/pdbsum/2g62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g62 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTPA_HUMAN PTPA_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.<ref>PMID:17333320</ref> <ref>PMID:16916641</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/2g62_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g62 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human PTPA===
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==See Also==
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*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 16782712 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_16782712}}
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==About this Structure==
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2G62 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G62 OCA].
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==Reference==
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The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions., Magnusdottir A, Stenmark P, Flodin S, Nyman T, Hammarstrom M, Ehn M, Bakali H MA, Berglund H, Nordlund P, J Biol Chem. 2006 Aug 11;281(32):22434-8. Epub 2006 Jun 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16782712 16782712]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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[[Category: Large Structures]]
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[[Category: Hydrolase activator]]
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[[Category: Arrowsmith C]]
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[[Category: Mgc2184]]
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[[Category: Berglund H]]
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[[Category: Pp2a]]
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[[Category: Collins R]]
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[[Category: Ppp2r4]]
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[[Category: Edwards A]]
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[[Category: Pr53]]
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[[Category: Ehn M]]
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[[Category: Protein phosphatase 2a]]
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[[Category: Flodin S]]
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[[Category: Ptpa]]
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[[Category: Flores A]]
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[[Category: Graslund S]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Dec 5 09:44:54 2008''
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[[Category: Hallberg BM]]
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[[Category: Hammarstrom M]]
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[[Category: Hogbom M]]
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[[Category: Holmberg Schiavone L]]
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[[Category: Kotenyova T]]
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[[Category: Magnusdottir A]]
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[[Category: Nilsson-Ehle P]]
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[[Category: Nordlund P]]
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[[Category: Nyman T]]
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[[Category: Ogg D]]
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[[Category: Persson C]]
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[[Category: Sagemark J]]
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[[Category: Stenmark P]]
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[[Category: Sundstrom M]]
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[[Category: Thorsell AG]]
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[[Category: Van Den Berg S]]
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[[Category: Wallden K]]
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[[Category: Weigelt J]]

Current revision

Crystal structure of human PTPA

PDB ID 2g62

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OCA

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