2ip6

<table><tr><td colspan='2'>[[2ip6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"pediococcus_hennebergii"_sollied_1903 "pediococcus hennebergii" sollied 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IP6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2IP6 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2ip6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ip6 OCA], [http://pdbe.org/2ip6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ip6 RCSB], [http://www.ebi.ac.uk/pdbsum/2ip6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ip6 ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

BACKGROUND: Pediocin-like bacteriocins, ribosomally-synthesized antimicrobial peptides, are generally coexpressed with cognate immunity proteins in order to protect the bacteriocin-producer from its own bacteriocin. As a step for understanding the mode of action of immunity proteins, we determined the crystal structure of PedB, a pediocin-like immunity protein conferring immunity to pediocin PP-1. RESULTS: The 1.6 A crystal structure of PedB reveals that PedB consists of an antiparallel four-helix bundle with a flexible C-terminal end. PedB shows structural similarity to an immunity protein against enterocin A (EntA-im) but some disparity to an immunity protein against carnobacteriocin B2 (ImB2) in both the C-terminal conformation and the local structure constructed by alpha3, alpha4, and their connecting loop. Structure-inspired mutational studies reveal that deletion of the last seven residues of the C-terminus of PedB almost abolished its immunity activity. CONCLUSION: The fact that PedB, EntA-im, and ImB2 share a four-helix bundle structure strongly suggests the structural conservation of this motif in the pediocin-like immunity proteins. The significant difference in the core structure and the C-terminal conformation provides a structural basis for the classification of pediocin-like immunity proteins. Our mutational study using C-terminal-shortened PedBs and the investigation of primary sequence of the C-terminal region, propose that several polar or charged residues in the extreme C-terminus of PedB which is crucial for the immunity are involved in the specific recognition of pediocin PP-1.

High resolution crystal structure of PedB: a structural basis for the classification of pediocin-like immunity proteins.,Kim IK, Kim MK, Kim JH, Yim HS, Cha SS, Kang SO BMC Struct Biol. 2007 May 30;7:35. PMID:17537233<ref>PMID:17537233</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2ip6" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Pediococcus hennebergii sollied 1903]]

[[Category: Cha, S S]]

[[Category: Kang, S O]]

[[Category: Kim, I K]]

[[Category: Kim, J H]]

[[Category: Kim, M K]]

[[Category: Yim, H S]]

[[Category: Antimicrobial protein]]

[[Category: Immunity protein to the pediocin pp-1]]