This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2yy9
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='2yy9' size='340' side='right'caption='[[2yy9]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='2yy9' size='340' side='right'caption='[[2yy9]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2yy9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2yy9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YY9 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yy9 OCA], [https://pdbe.org/2yy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yy9 RCSB], [https://www.ebi.ac.uk/pdbsum/2yy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yy9 ProSAT], [https://www.topsan.org/Proteins/RSGI/2yy9 TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yy9 OCA], [https://pdbe.org/2yy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yy9 RCSB], [https://www.ebi.ac.uk/pdbsum/2yy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yy9 ProSAT], [https://www.topsan.org/Proteins/RSGI/2yy9 TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/TZAP_MOUSE TZAP_MOUSE] Telomere-binding protein that acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Regulates expression the J and/or S elements in MHC II promoter. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A.[UniProtKB:P10074] | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 22: | Line 22: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: Kishishita | + | [[Category: Kishishita S]] |
| - | [[Category: Murayama | + | [[Category: Murayama K]] |
| - | [[Category: Nishino | + | [[Category: Nishino A]] |
| - | + | [[Category: Shirouzu M]] | |
| - | [[Category: Shirouzu | + | [[Category: Terada T]] |
| - | [[Category: Terada | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Crystal structure of BTB domain from mouse HKR3
| |||||||||||
