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2zfu

From Proteopedia

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{{Seed}}
 
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[[Image:2zfu.png|left|200px]]
 
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==Structure of the methyltransferase-like domain of nucleomethylin==
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The line below this paragraph, containing "STRUCTURE_2zfu", creates the "Structure Box" on the page.
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<StructureSection load='2zfu' size='340' side='right'caption='[[2zfu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2zfu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZFU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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{{STRUCTURE_2zfu| PDB=2zfu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zfu OCA], [https://pdbe.org/2zfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zfu RCSB], [https://www.ebi.ac.uk/pdbsum/2zfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zfu ProSAT]</span></td></tr>
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</table>
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===Structure of the methyltransferase-like domain of nucleomethylin===
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== Function ==
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[https://www.uniprot.org/uniprot/RRP8_HUMAN RRP8_HUMAN] Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.<ref>PMID:18485871</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_18485871}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 18485871 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zf/2zfu_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18485871}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2ZFU is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZFU OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zfu ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Epigenetic control of rDNA loci in response to intracellular energy status., Murayama A, Ohmori K, Fujimura A, Minami H, Yasuzawa-Tanaka K, Kuroda T, Oie S, Daitoku H, Okuwaki M, Nagata K, Fukamizu A, Kimura K, Shimizu T, Yanagisawa J, Cell. 2008 May 16;133(4):627-39. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18485871 18485871]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hashimoto, H.]]
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[[Category: Large Structures]]
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[[Category: Minami, H.]]
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[[Category: Hashimoto H]]
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[[Category: Murayama, A.]]
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[[Category: Minami H]]
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[[Category: Sato, M.]]
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[[Category: Murayama A]]
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[[Category: Shimizu, T.]]
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[[Category: Sato M]]
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[[Category: Yanagisawa, J.]]
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[[Category: Shimizu T]]
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[[Category: Nuclear protein]]
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[[Category: Yanagisawa J]]
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[[Category: Nucleolar protein]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Protein structure]]
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[[Category: Sam-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 10 15:33:24 2008''
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Current revision

Structure of the methyltransferase-like domain of nucleomethylin

PDB ID 2zfu

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