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2zgk

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{{Seed}}
 
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[[Image:2zgk.png|left|200px]]
 
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<!--
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==Crystal structure of wildtype AAL==
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The line below this paragraph, containing "STRUCTURE_2zgk", creates the "Structure Box" on the page.
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<StructureSection load='2zgk' size='340' side='right'caption='[[2zgk]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2zgk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cyclocybe_aegerita Cyclocybe aegerita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZGK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zgk OCA], [https://pdbe.org/2zgk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zgk RCSB], [https://www.ebi.ac.uk/pdbsum/2zgk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zgk ProSAT]</span></td></tr>
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{{STRUCTURE_2zgk| PDB=2zgk | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of wildtype AAL===
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[https://www.uniprot.org/uniprot/ATLE_CYCAE ATLE_CYCAE] Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells. Binds N-acetylneuraminyl lactose (N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose) (PubMed:16051274).<ref>PMID:12757412</ref> <ref>PMID:16051274</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<!--
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_19361423}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 19361423 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zg/2zgk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_19361423}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zgk ConSurf].
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2ZGK is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Agrocybe_aegerita Agrocybe aegerita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZGK OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:19361423</ref><references group="xtra"/>
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__TOC__
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[[Category: Agrocybe aegerita]]
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</StructureSection>
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[[Category: Li, D F.]]
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[[Category: Cyclocybe aegerita]]
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[[Category: Wang, D C.]]
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[[Category: Large Structures]]
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[[Category: Yang, N.]]
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[[Category: Li DF]]
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[[Category: Apoptosis]]
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[[Category: Wang DC]]
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[[Category: Galectin]]
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[[Category: Yang N]]
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[[Category: Hydrolase]]
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[[Category: Jelly roll]]
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[[Category: Nuclease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 10 17:10:15 2009''
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Current revision

Crystal structure of wildtype AAL

PDB ID 2zgk

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