This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2znr
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2znr is ON HOLD until Paper Publication Authors: Sato, Y., Yoshikawa, A., Yamagata, A., Mimura, H., Wang, X., Yamashita, M., Ookata, K., Nureki, O.,...) |
|||
| (9 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the DUB domain of human AMSH-LP== | |
| - | + | <StructureSection load='2znr' size='340' side='right'caption='[[2znr]], [[Resolution|resolution]] 1.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2znr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZNR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZNR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2znr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2znr OCA], [https://pdbe.org/2znr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2znr RCSB], [https://www.ebi.ac.uk/pdbsum/2znr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2znr ProSAT]</span></td></tr> | |
| - | + | </table> | |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/STALP_HUMAN STALP_HUMAN] Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains.<ref>PMID:18758443</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zn/2znr_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2znr ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Azusa Y]] | ||
| + | [[Category: Fukai S]] | ||
| + | [[Category: Iwai K]] | ||
| + | [[Category: Komada M]] | ||
| + | [[Category: Mimura H]] | ||
| + | [[Category: Nureki O]] | ||
| + | [[Category: Ookata K]] | ||
| + | [[Category: Sato Y]] | ||
| + | [[Category: Wang X]] | ||
| + | [[Category: Yamagata A]] | ||
| + | [[Category: Yamashita M]] | ||
Current revision
Crystal structure of the DUB domain of human AMSH-LP
| |||||||||||
Categories: Homo sapiens | Large Structures | Azusa Y | Fukai S | Iwai K | Komada M | Mimura H | Nureki O | Ookata K | Sato Y | Wang X | Yamagata A | Yamashita M
